Cells can sense, respond and adapt to physical surroundings and translate the mechanical information to shape their functions. How does this happen? Over the past few decades, mechanobiology emerged as an encouraging field trying to open the door by integrating the interface between physics and biochemistry in organisms. Tons of proteins, organelles and signaling pathways have been explored to be sensitive to mechanical surroundings and
consequently responsible for specific functions, pinpointing these specific types of machinery may lead to future targeting sites for disease therapies. By unravelling the network of complexity inherent to mechanobiology, the prospect of this field contributing to the future directions of bench research and clinical applications is promising.
Cells can process the mechanical information through multiple-scale structures from mechanosensitive ion channels (-nm) to skeletal complexes (-µm) like cilia and flagella. Beyond the single cellular machinery, the communication among millions of cells can be triggered by the self-reorganization and remodeling through a single multi-scale super-organism activity. The diversity of mechano-response of biological components scaling from individual proteins to cellular populations reveals the complexity of underlying translation and transduction process. Understanding multiple-scale machineries is therefore essential to unravel the hierarchy and interconnectivity inherent to mechanobiology. The prospect of this field contributing to the future directions of bench research and clinical applications is promising. This Research Topic “Mechanobiology at multiple scales” invites authors to contribute original scientific reports, articles, and reviews that cover the recent advances in all aspects of mechanobiology.
• Mechanobiology during tissue morphogenesis
• Mechanobiology in disease
• Advanced multiple-scale approaches for mechanobiology
• Simulation tools for mechanobiology
• Experimental technology for mechanobiology
• Modelling in mechanobiology
• Cell mechanics
Cells can sense, respond and adapt to physical surroundings and translate the mechanical information to shape their functions. How does this happen? Over the past few decades, mechanobiology emerged as an encouraging field trying to open the door by integrating the interface between physics and biochemistry in organisms. Tons of proteins, organelles and signaling pathways have been explored to be sensitive to mechanical surroundings and
consequently responsible for specific functions, pinpointing these specific types of machinery may lead to future targeting sites for disease therapies. By unravelling the network of complexity inherent to mechanobiology, the prospect of this field contributing to the future directions of bench research and clinical applications is promising.
Cells can process the mechanical information through multiple-scale structures from mechanosensitive ion channels (-nm) to skeletal complexes (-µm) like cilia and flagella. Beyond the single cellular machinery, the communication among millions of cells can be triggered by the self-reorganization and remodeling through a single multi-scale super-organism activity. The diversity of mechano-response of biological components scaling from individual proteins to cellular populations reveals the complexity of underlying translation and transduction process. Understanding multiple-scale machineries is therefore essential to unravel the hierarchy and interconnectivity inherent to mechanobiology. The prospect of this field contributing to the future directions of bench research and clinical applications is promising. This Research Topic “Mechanobiology at multiple scales” invites authors to contribute original scientific reports, articles, and reviews that cover the recent advances in all aspects of mechanobiology.
• Mechanobiology during tissue morphogenesis
• Mechanobiology in disease
• Advanced multiple-scale approaches for mechanobiology
• Simulation tools for mechanobiology
• Experimental technology for mechanobiology
• Modelling in mechanobiology
• Cell mechanics