About this Research Topic

Background

Cancer is usually treated as a homogeneous disease. During cancer progression, however, tumors become highly heterogeneous, creating a mixed population of cells characterized by different molecular features and diverse responsiveness to therapies. With the development of high-throughput molecular technologies, including multi-omic approaches, we now have access to large pools of data that can be used to explore many aspects of carcinogenesis, and anticancer drug response and resistance. Moreover, new tools are now available to design better therapeutic strategies including molecular docking, nanotechnology and cell therapy).

This Research Topic aims to highlight the emerging role of modalities based on multi-omics studies to understand the biology of different types of cancer and the development of novel anti-cancer therapies.

We welcome Original Research, Review, and Mini-Review articles that describe and cover the recent advances made in the molecular and multi-omics aspects of cancer research and anticancer drug development, with a specific focus on strategies aiming to overcome drug resistance and adverse side effects.

This Research Topic include the following sub-topics, but are not limited to:

1. Multidisciplinary studies for the molecular understanding of cancers. (e.g. Genetic, genomic, epigenetic analysis; Proteomic & metabolomic analysis; Transcriptomic analysis; and Single-cell analysis)

2. Multidisciplinary studies for a better understanding of the mechanisms and methods to overcome anticancer drug resistance and toxicities (incl. chemotherapy, targeted therapy, immunotherapy and cell therapy).

Keywords: Carcinogenesis, anticancer therapy, anticancer resistance, anticancer toxicities, immunooncology, non-coding RNA, multi-omics, cancer epigenetics.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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