Cerebrospinal fluid (CSF) circulation disorders such as hydrocephalus are known to cause many unknown aspects in the pathophysiology, diagnosis, and treatment of CSF dyscrasia. Concussion, head injury, Chiari malformation, syringomyelia, brain tumour, strokes, and some cerebrovascular diseases also can lead to disruption of CSF circulation. Modelling and simulation of CSF disorders aim to gain insight into the ambiguous points related to the mechanism and management of the disease. Clarifying these complexities can be difficult for physicians as common neuroimages and clinical symptoms can be confusing and difficult to diagnose and treat. Recent advances in bioengineering have facilitated utilizing developed modelling and simulation in the prognosis and management of CSF disorders as well as the evaluation of symptom severity and surgical outcomes of these patients. However, there are many challenging and controversial points in these models and simulations such as optimal simulation that resembles real physiological conditions. Hence, more comprehensive studies will be required to clarify these complexities.
Many CSF disorders are misdiagnosed because of clinical overlaps. Hence, we need more accurate indicators in addition to neurological and physical examinations, symptoms, and histories of patients, to distinguish the diagnosis of these disorders. Bioengineering parameters can be powerful tools for evaluating these disorders quantitatively. There is also no definitive treatment method for many CSF disorders. This can be due to a lack of knowledge about the mechanism of these disorders. In vitro models measure very limited parameters and have limitations in mechanism studies. Animal studies are another alternative, but the transferability of animal studies to human subjects is neither easy nor reliable. Assessment of various dynamic conditions of patients including coughing, sneezing, Valsalva manoeuvres, cardiac exercises and respiratory pulses, and irregular disorders that occur after strenuous exercise in most animal and human studies are impossible and can have many ethical issues. Developed modelling and simulations can help enhance a "neuroscientific" insight into the mechanism of CSF disorders as well as their diagnosis and treatments non-invasively.
This collection is interested in publishing high-quality Original Research and Review articles in all aspects of the rapidly expanding area of modelling, numerical investigation, mathematical analysis, theoretical studies, and computer simulation in CSF disorders.
Articles that examine the following topics of special interest are being featured in this Research Topic:
• Computer simulation of CSF dynamics
• Image-based simulation of CSF disorders
• Numerical and mathematical analysis of CSF flow
• CSF and brain drug delivery system
• Modeling of blood-brain and blood–CSF barriers
• Theoretical analysis of CSF circulation disorders
• Brain biomechanics
• Simulation of shunt and ETV surgeries
• Biotechnological studies of CSF
The Topic Editors declare no competing interests in regards to affiliations to private companies, founding of a private company, receiving of grants from a private company, holding shares of a private company, and/or holding patents.
Cerebrospinal fluid (CSF) circulation disorders such as hydrocephalus are known to cause many unknown aspects in the pathophysiology, diagnosis, and treatment of CSF dyscrasia. Concussion, head injury, Chiari malformation, syringomyelia, brain tumour, strokes, and some cerebrovascular diseases also can lead to disruption of CSF circulation. Modelling and simulation of CSF disorders aim to gain insight into the ambiguous points related to the mechanism and management of the disease. Clarifying these complexities can be difficult for physicians as common neuroimages and clinical symptoms can be confusing and difficult to diagnose and treat. Recent advances in bioengineering have facilitated utilizing developed modelling and simulation in the prognosis and management of CSF disorders as well as the evaluation of symptom severity and surgical outcomes of these patients. However, there are many challenging and controversial points in these models and simulations such as optimal simulation that resembles real physiological conditions. Hence, more comprehensive studies will be required to clarify these complexities.
Many CSF disorders are misdiagnosed because of clinical overlaps. Hence, we need more accurate indicators in addition to neurological and physical examinations, symptoms, and histories of patients, to distinguish the diagnosis of these disorders. Bioengineering parameters can be powerful tools for evaluating these disorders quantitatively. There is also no definitive treatment method for many CSF disorders. This can be due to a lack of knowledge about the mechanism of these disorders. In vitro models measure very limited parameters and have limitations in mechanism studies. Animal studies are another alternative, but the transferability of animal studies to human subjects is neither easy nor reliable. Assessment of various dynamic conditions of patients including coughing, sneezing, Valsalva manoeuvres, cardiac exercises and respiratory pulses, and irregular disorders that occur after strenuous exercise in most animal and human studies are impossible and can have many ethical issues. Developed modelling and simulations can help enhance a "neuroscientific" insight into the mechanism of CSF disorders as well as their diagnosis and treatments non-invasively.
This collection is interested in publishing high-quality Original Research and Review articles in all aspects of the rapidly expanding area of modelling, numerical investigation, mathematical analysis, theoretical studies, and computer simulation in CSF disorders.
Articles that examine the following topics of special interest are being featured in this Research Topic:
• Computer simulation of CSF dynamics
• Image-based simulation of CSF disorders
• Numerical and mathematical analysis of CSF flow
• CSF and brain drug delivery system
• Modeling of blood-brain and blood–CSF barriers
• Theoretical analysis of CSF circulation disorders
• Brain biomechanics
• Simulation of shunt and ETV surgeries
• Biotechnological studies of CSF
The Topic Editors declare no competing interests in regards to affiliations to private companies, founding of a private company, receiving of grants from a private company, holding shares of a private company, and/or holding patents.
