Role of Non-coding RNAs, Metabolites and Extracellular Vesicles in Disease Regulation and Health

  • 14k

    Total Downloads

  • 46k

    Total Views and Downloads

About this Research Topic

Submission closed

Background

Non-coding Ribonucleic Acids are involved in epigenetic regulation directly silencing or activating chromatin at specific loci or through their integrated role into the machinery driving DNA methylation. Small RNAs, including short interfering RNAs (siRNAs) and microRNAs (miRNAs), mediate post-transcriptional gene silencing by RNA interference (RNAi) or have direct activity in the nucleosomes. These molecules are opening new avenues for therapeutic purposes or for assaying exogenous non-coding RNA acquisition on the immunity not only of the host, but also the putative consequences for generations on immunity, including allergic inflammation, cancer, or interactions with host microbiota. miRNA or siRNA are used as molecular therapies for environmental stress and metabolic diseases (obesity, Type-1, and 2 diabetes, metabolic syndrome). These molecules can also be supplied as exogenous molecules with various vectors manipulating host non-specific or specific immune responses. Therefore, developing formulations that are suitable and can be applied to the oral delivery of miRNAs is in high demand. However, miRNA availability is highly challenging due to nucleic acid degradation in the gastric environment.
Almost all types of cells release extracellular vesicles (EVs) into the extracellular space. EVs such as exosomes and microvesicles are membrane-bound vesicles ranging in size from 30 to 1000 nm in diameter. Under normal conditions, EVs mediate cell to cell as well as inter-organ communication via the shuttling of their cargoes which include RNA, DNA, and proteins. Under pathological conditions, however, the number, size and content of EVs are found to be altered and have been shown to play crucial roles in disease progression. Emerging studies have demonstrated that EVs are involved in many aspects of viral infection-mediated neurodegenerative diseases. Furthermore, host bacteria can produce extracellular vesicles (EVs) containing non-coding RNAs that can mediate intercellular communication with epithelial and immune cells and potentially regulate the expression of genes involved in controlling the resistance to pathologies. On the other hand, host cells can also deliver non-coding RNAs to bacteria and similarly, regulate gene expression.
Metabolites are end-products or intermediates in metabolic pathways, and they constitute the chemical fingerprints of an organism. Metabolites modulate several cellulars and molecular events such as signalling pathways, energy conversation, and enzyme activities; therefore, the metabolomic profile of an organism plays an important role in determining its disease condition and health and are becoming an essential diagnostic signature.

We welcome the submission of Original Research, Reviews, and Mini-Reviews articles, as well as Methods, Hypothesis and Theory, Perspective, Clinical Trial, Opinion, and Systematic Review articles. The following themes can be addressed in this Research Topic:
We welcome the submission of Original Research, Reviews, and Mini-Reviews articles, as well as Methods, Hypothesis and Theory, Perspective, Clinical Trial, Opinion, and Systematic Review articles. The following themes can be addressed in this Research Topic:
(1) The use of noncoding RNAs in molecular immunotherapy facing environmental stress and metabolic diseases.
(2) The role of Extracellular Vesicles in disease biology and EVs as therapeutic tools.
(3) Gut microbiota as a new player in regulating immune- and chemo-therapy efficacy through non-coding-RNA. Targeting immune cells from the gut to treat inflammatory diseases or infection with Extracellular vesicles or biomimetic nanovectors. The scope is implementing microRNA as a new immune-regulatory agent in breast milk, the sequence-non-specific effects of the miRNA delivered to cells with appropriate carriers or expressed in cells using suitable vectors often trigger both intended sequence-specific silencing effects and unintended sequence-non-specific immune responses.
(4) Understanding the role of metabolites and cross-talk with genetic and epigenetic mechanisms in controlling cellular functioning.

Keywords: small molecules, non-coding RNAs, transcription factor, gene regulation, immune response

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and they fall under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

      In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Participating Journals

Impact

  • 46kTopic views
  • 31kArticle views
  • 14kArticle downloads
View impact