Regulation and Coordination of the Different DNA Damage Responses and their Role in Tissue Homeostasis Maintenance

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Background

Cells have evolved mechanisms that allow them to respond to DNA damage to preserve genomic integrity and maintain tissue homeostasis. DNA damage activates complex DNA signalling networks that decide the fate of the cell, inducing survival pathways, DNA repair, cell cycle arrest, or the induction of apoptosis that will eventually eliminate damaged cells. These “life” vs “death” cell fate decisions differ depending on the cell type, stages of development, and the proliferation status of the cell. Alterations in signaling pathways that control and coordinate these responses can lead to numerous diseases such as developmental defects and cancer. Multiples studies have elucidated the molecular mechanisms that mediate the activation of the DNA damage response pathway, however much less is known about how the different responses, such as cell proliferation control and apoptosis, are coordinated to maintain tissue homeostasis. Another interesting question is how the differential apoptotic response to DNA damage is regulated in different cell types. The existence of intrinsic mechanisms that might attenuate the apoptotic pathway in response to DNA damage may well account for the differences in the clinical responsiveness of tumor cells after radiation therapy.
The aim of this Research Topic is to obtain genetic and molecular mechanistic insights into how the different DNA damage responses are regulated and coordinated in different cellular contexts and at different developmental stages.
This Research Topic welcomes Original Research articles, Review articles, Mini Review articles and Brief Research Report articles that focus on but are not limited to the following topics:
- Crosstalk mechanisms between the different DNA damage responses
-Identification of new components involved in the coordination of the different cellular responses after DNA damage
-Cell cycle progression influences on the ability of cells to undergo DNA damage-induced apoptosis
- Molecular and genetic mechanisms that attenuate or block DNA damage-induced apoptosis in different cell types
- Identification of new molecular elements involved in DNA damage-induced tumorigenesis

Keywords: DNA damage response, cell cycle, radioresistance, Apoptotic pathway, checkpoint, Cancer

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