Serving as a vehicle for transfer between cells, extracellular vesicles (EVs), including microvesicles (MVs), exosomes and apoptotic bodies, are important modes of intercellular communication. The application of EVs in the clinical for diagnosis, prognosis, therapy, and drug delivery carrier has been well-demonstrated and continues to be an intense subject of study with ever-growing literatures. As carriers of biomarkers, EVs are attracting considerable interests in the scientific community due to their role in intercellular communication. Depending on the cell of origin, EVs can contain many constituents of a cell, including DNA, RNA, lipids, metabolites, cytosolic and cell-surface proteins.
Within the past decade, EVs have emerged as important mediators of intercellular communication, involved in the transmission of biological signals to regulate a diverse range of biological processes. EVs are associated with immune responses, viral pathogenicity, cancer progression. Especially in coronary artery disease, accumulated EVs in human atherosclerotic plaques induce major pathological pathways, including inflammation, thrombosis and calcification, and contribute to the development and progression of atherosclerosis. Also, EVs released by healthy cells or stem cells have potential therapeutic benefits on cardiovascular disease. Recently, EVs can be engineered to deliver diverse therapeutic payloads, including short interfering RNAs, antisense oligonucleotides, chemotherapeutic agents, and immune modulators, with an ability to direct their delivery to a desired target. The physiological and pathological purpose of generating EVs remains largely unknown and needs to be further investigated.
The aim of this Research Topic is to gather a comprehensive list of articles related to the mechanistic investigation of Extracellular Vesicles and its translational applications in Cardiovascular Disease. The collection will cover various aspects spanning from basic research to translational and clinical developments related to extracellular vesicles.
We welcome submission of Original Research Articles, Reviews and Mini-Reviews, including the following topics:
- Novel cellular and molecular mechanisms of extracellular vesicles including membrane trafficking and protein sorting
- Effects of extracellular vesicles on the development of atherosclerosis
- Diagnosis and therapy of extracellular vesicles in cardiovascular disease
- Advanced techniques and quantitative characterization in the isolation, quantification and characterization of extracellular vesicles
Serving as a vehicle for transfer between cells, extracellular vesicles (EVs), including microvesicles (MVs), exosomes and apoptotic bodies, are important modes of intercellular communication. The application of EVs in the clinical for diagnosis, prognosis, therapy, and drug delivery carrier has been well-demonstrated and continues to be an intense subject of study with ever-growing literatures. As carriers of biomarkers, EVs are attracting considerable interests in the scientific community due to their role in intercellular communication. Depending on the cell of origin, EVs can contain many constituents of a cell, including DNA, RNA, lipids, metabolites, cytosolic and cell-surface proteins.
Within the past decade, EVs have emerged as important mediators of intercellular communication, involved in the transmission of biological signals to regulate a diverse range of biological processes. EVs are associated with immune responses, viral pathogenicity, cancer progression. Especially in coronary artery disease, accumulated EVs in human atherosclerotic plaques induce major pathological pathways, including inflammation, thrombosis and calcification, and contribute to the development and progression of atherosclerosis. Also, EVs released by healthy cells or stem cells have potential therapeutic benefits on cardiovascular disease. Recently, EVs can be engineered to deliver diverse therapeutic payloads, including short interfering RNAs, antisense oligonucleotides, chemotherapeutic agents, and immune modulators, with an ability to direct their delivery to a desired target. The physiological and pathological purpose of generating EVs remains largely unknown and needs to be further investigated.
The aim of this Research Topic is to gather a comprehensive list of articles related to the mechanistic investigation of Extracellular Vesicles and its translational applications in Cardiovascular Disease. The collection will cover various aspects spanning from basic research to translational and clinical developments related to extracellular vesicles.
We welcome submission of Original Research Articles, Reviews and Mini-Reviews, including the following topics:
- Novel cellular and molecular mechanisms of extracellular vesicles including membrane trafficking and protein sorting
- Effects of extracellular vesicles on the development of atherosclerosis
- Diagnosis and therapy of extracellular vesicles in cardiovascular disease
- Advanced techniques and quantitative characterization in the isolation, quantification and characterization of extracellular vesicles
