Musculoskeletal disorders and diseases are the leading cause of disability in the United States, accounting for more than half of all chronic conditions in people over age 50. The costs dwarf those of other conditions, coming close to 8% of the U.S. gross domestic product. Arthritis, pain, trauma and frailty are key conditions that drive this societal burden. Each of these conditions are associated with a myriad of complex physiological changes not only involving the musculoskeletal system, but also the nervous system through integrated feedback and feedforward processes.
This Research Topic for Frontiers in Physiology focuses on the physiological mechanisms, as well as effects and consequences, of pain (e.g., arthritis, trauma, etc.) as well as aging (e.g., frailty, sarcopenia, osteoporosis). The goal is to highlight both basic and applied physiology work with particular relevance to these highly prevalent and burdensome musculoskeletal conditions.
In addition to traditional physiology-type articles, we also welcome and encourage innovative articles that work to integrate the physiological effects across multiple systems, such as 1) the neuroplastic and psychophysical effects associated with pain and/or traumatic injury; 2) new and innovative approaches to address pain and/or aging-related losses in physiological function from an engineering perspective; and 3) cross-tissue maintenance of whole-body metabolism. Original research and review article submissions are welcome in this Research Topic.
The Guest Editors encourage all interested individuals and research groups to submit an abstract before submitting their manuscript. Abstract submission deadline: 30 July 2021.
In the past 5-years, Topic Editor Dr. Brian Clark has received research funding from NMD Pharma, Regeneron Pharmaceuticals, Astellas Pharma Global Development, Inc., and RTI Health Solutions for contracted studies that involved aging and muscle related research. In the past 5-years, Brian Clark has received consulting fees from Regeneron Pharmaceuticals, Zev industries, and the Gerson Lehrman Group for consultation specific to age-related muscle weakness. Brian Clark is a co-founder with equity of OsteoDx Inc., which is seeking commercialize instruments and devices to quantify the mechanical properties of bone.
Topic Editor Dr. Dustin Grooms has investor shares for intellectual contributions toward in an augmented reality biofeedback product for injury prevention and recovery training currently in a license agreement with Include Health Inc.
In the past 5-years, Topic Editor Dr. W. David Arnold has received research funding from NMD Pharma and Biogen related to neuromuscular and age-related disorder research. In the past 5-years, W. David Arnold has received consulting fees from Avidity Biosciences, Genentech, La Hoffman Roche, and Novartis related to age-associated genetic neuromuscular disorders.
All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Musculoskeletal disorders and diseases are the leading cause of disability in the United States, accounting for more than half of all chronic conditions in people over age 50. The costs dwarf those of other conditions, coming close to 8% of the U.S. gross domestic product. Arthritis, pain, trauma and frailty are key conditions that drive this societal burden. Each of these conditions are associated with a myriad of complex physiological changes not only involving the musculoskeletal system, but also the nervous system through integrated feedback and feedforward processes.
This Research Topic for Frontiers in Physiology focuses on the physiological mechanisms, as well as effects and consequences, of pain (e.g., arthritis, trauma, etc.) as well as aging (e.g., frailty, sarcopenia, osteoporosis). The goal is to highlight both basic and applied physiology work with particular relevance to these highly prevalent and burdensome musculoskeletal conditions.
In addition to traditional physiology-type articles, we also welcome and encourage innovative articles that work to integrate the physiological effects across multiple systems, such as 1) the neuroplastic and psychophysical effects associated with pain and/or traumatic injury; 2) new and innovative approaches to address pain and/or aging-related losses in physiological function from an engineering perspective; and 3) cross-tissue maintenance of whole-body metabolism. Original research and review article submissions are welcome in this Research Topic.
The Guest Editors encourage all interested individuals and research groups to submit an abstract before submitting their manuscript. Abstract submission deadline: 30 July 2021.
In the past 5-years, Topic Editor Dr. Brian Clark has received research funding from NMD Pharma, Regeneron Pharmaceuticals, Astellas Pharma Global Development, Inc., and RTI Health Solutions for contracted studies that involved aging and muscle related research. In the past 5-years, Brian Clark has received consulting fees from Regeneron Pharmaceuticals, Zev industries, and the Gerson Lehrman Group for consultation specific to age-related muscle weakness. Brian Clark is a co-founder with equity of OsteoDx Inc., which is seeking commercialize instruments and devices to quantify the mechanical properties of bone.
Topic Editor Dr. Dustin Grooms has investor shares for intellectual contributions toward in an augmented reality biofeedback product for injury prevention and recovery training currently in a license agreement with Include Health Inc.
In the past 5-years, Topic Editor Dr. W. David Arnold has received research funding from NMD Pharma and Biogen related to neuromuscular and age-related disorder research. In the past 5-years, W. David Arnold has received consulting fees from Avidity Biosciences, Genentech, La Hoffman Roche, and Novartis related to age-associated genetic neuromuscular disorders.
All other Topic Editors declare no competing interests with regards to the Research Topic subject.
