Nutrients and their metabolites exert an important influence on the epigenetic state of cells, as they serve as substrate and/or coenzymes for epigenetic-modifying enzymes. Retrospectively, gene expression of several key metabolic pathways is regulated by the epigenetic state of the chromatin, thereby facilitating metabolic adaptation. Metabolic-epigenetic feedback is determinant for stem cell differentiation, cancer cells proliferation, and activating the immune system. The role of this feedback is more prominent in chronic metabolic disorders such as obesity, diabetes, and cancer, in which pre- and post-natal nutrient uptake/signaling influence the susceptibility for the disease. Understanding the possible mechanisms of metabolic-epigenetic crosstalk in these specific contexts will create opportunities to improve disease management.
Despite many emerging approaches becoming available for metabolomics data and high-throughput sequencing data to infer metabolic and epigenetic regulations, it remains challenging to establish the multi-level interactions between metabolic regulation and epigenetic factors. Moreover, the causal relationships among nutrition, epigenetics and complex phenotypic traits are to be further investigated. Therefore, the aims of this Research Topic are 1) to collect research data that uses cutting-edge approaches to study the metabolic and epigenetic crosstalk at a cellular and organismal level, 2) to understand the molecular mechanisms underlying epigenetic reprogramming mediated by metabolic switch in physiology and pathology, 3) to manipulate favorable epigenetic elements to improve metabolic disorders, and 4) to facilitate research efforts in the area of knowledge creation and disease management.
We welcome Original Research articles, Methods, Data Reports, Reviews, Mini-Reviews, and Systematic Reviews to submit to this Research Topic. Here are some specific themes we would like contributors to address:
1) Crosstalk between metabolites and epigenetic marks (histone modifications, DNA methylation, epigenetic machineries post-translational modifications) and their biological function
2) Metabolites and nutrition – induced epigenetic changes in development and disease
3) Technological development for measuring axis of metabolism and epigenetics programing
4) Epigenetic alterations and their implications on metabolic reprogramming of cancer and stem cells
Nutrients and their metabolites exert an important influence on the epigenetic state of cells, as they serve as substrate and/or coenzymes for epigenetic-modifying enzymes. Retrospectively, gene expression of several key metabolic pathways is regulated by the epigenetic state of the chromatin, thereby facilitating metabolic adaptation. Metabolic-epigenetic feedback is determinant for stem cell differentiation, cancer cells proliferation, and activating the immune system. The role of this feedback is more prominent in chronic metabolic disorders such as obesity, diabetes, and cancer, in which pre- and post-natal nutrient uptake/signaling influence the susceptibility for the disease. Understanding the possible mechanisms of metabolic-epigenetic crosstalk in these specific contexts will create opportunities to improve disease management.
Despite many emerging approaches becoming available for metabolomics data and high-throughput sequencing data to infer metabolic and epigenetic regulations, it remains challenging to establish the multi-level interactions between metabolic regulation and epigenetic factors. Moreover, the causal relationships among nutrition, epigenetics and complex phenotypic traits are to be further investigated. Therefore, the aims of this Research Topic are 1) to collect research data that uses cutting-edge approaches to study the metabolic and epigenetic crosstalk at a cellular and organismal level, 2) to understand the molecular mechanisms underlying epigenetic reprogramming mediated by metabolic switch in physiology and pathology, 3) to manipulate favorable epigenetic elements to improve metabolic disorders, and 4) to facilitate research efforts in the area of knowledge creation and disease management.
We welcome Original Research articles, Methods, Data Reports, Reviews, Mini-Reviews, and Systematic Reviews to submit to this Research Topic. Here are some specific themes we would like contributors to address:
1) Crosstalk between metabolites and epigenetic marks (histone modifications, DNA methylation, epigenetic machineries post-translational modifications) and their biological function
2) Metabolites and nutrition – induced epigenetic changes in development and disease
3) Technological development for measuring axis of metabolism and epigenetics programing
4) Epigenetic alterations and their implications on metabolic reprogramming of cancer and stem cells
