Probing the Ubiquitin Landscape

286.1K

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69

authors

19

articles

Probing the Ubiquitin Landscape

286.1K

views

69

authors

19

articles

Editorial

20 August 2020

In Memoriam: Professor Huib Ovaa (1973-2020): A Uniquely Brilliant and Enthusiastic Scientist, a Pioneer in Chemical Biology and the Ubiquitin Field

Monique P. C. Mulder

and

Benedikt M. Kessler

4,271 views

1 citations

Editors

5

Huib Ovaa

Leiden University Medical Center (LUMC)

Monique P. C. Mulder

Leiden University Medical Center (LUMC)

Zhihao Zhuang

University of Delaware

Benedikt M Kessler

Nuffield Department of Medicine, Medical Sciences Division, University of Oxford

L Liu

Tsinghua University

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About

Protein ubiquitination is a powerful post-translational modulator of cellular functions and is tightly controlled by the action of hundreds of regulatory (E1, E2, E3) and deubiquitinating enzymes (DUBs). Unlike most post-translational modifiers such as phosphorylation or acetylation, ubiquitination can be highly customized through further post-translational modification of ubiquitin itself, thereby coding for a distinct cellular outcome. Dysregulation of this intrinsic process is often associated with diseases that include cancer, autoimmunity, Alzheimer, and Parkinson’s disease.

Next to ubiquitin, a number of ubiquitin-like proteins (e.g. Sumo, Nedd8, Isg15, Ufm1, Fat10) can also be attached to proteins increasing the complexity of and fine-tuning cellular responses even further. To advance our understanding of one of the most complex and widespread signaling networks in biology, activity-based probes (ABPs), assay reagents as well as advanced proteomics techniques are key. Characterization of this dynamic field is imminent as the development of inhibitors of Ubiquitin(-like) system components has gained significant increase in interest recently.

The aim of the current Research Topic is to cover promising, recent, and novel research trends in the ubiquitin and ubiquitin-like field. Areas to be covered in this Research Topic may include, but are not limited to:

- Development of Activity Based Probes
- Application of the ubiquitin(-like) based toolbox in the study of the ubiquitin landscape
- Therapeutic strategies (e.g Assay development, PROTACs)
- Ubiquitin(-like) variants
- Advanced proteomic techniques

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Editors

Huib Ovaa

Leiden University Medical Center (LUMC)

Monique P. C. Mulder

Leiden University Medical Center (LUMC)

Zhihao Zhuang

University of Delaware

Benedikt M Kessler

Nuffield Department of Medicine, Medical Sciences Division, University of Oxford

L Liu

Tsinghua University

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286,069 Total views

219,110 Article views

42,859 Article downloads

24,100 Topic views

Published In

Frontiers in Chemistry

Chemical Biology, Cellular Biochemistry

Frontiers in Cell and Developmental Biology

Cellular Biochemistry

Frontiers in Molecular Biosciences

Cellular Biochemistry, Chemical Biology

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