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Systematic Review
16 April 2020
Psychophysiological Effects of Downregulating Negative Emotions: Insights From a Meta-Analysis of Healthy Adults
Jenny Zaehringer
3 more and 
Christian Paret
Number of available effect sizes for each measure as a function of emotion regulation strategy (distraction, reappraisal, suppression, own choice). Note that the statistic refers to the k = 78 studies initially identified in our qualitative analysis. cEMG, corrugator activity; CO, cardiac output; DBP, diastolic blood pressure; EPA, ear pulse amplitude; EPTT, ear pulse transit time; FPA, finger pulse amplitude; FPTT, finger pulse transit time; FT, finger temperature; HR, heart rate; HRV, heart rate variability; LF, low frequency HRV; LF/HF, ratio between low and high frequency HRV; MAP, mean arterial pressure; nSCR, number of skin conductance responses; PD, pupil dilation; PEP, pre-ejection period; RA, respiration amplitude; RR, respiration rate; SBP, systolic blood pressure; SCL, skin conductance level; SCR, skin conductance response; SV, stroke volume; TPR, total peripheral resistance; zEMG, zygomatic activity.

Assessing psychophysiological responses of emotion regulation is a cost-efficient way to quantify emotion regulation and to complement subjective report that may be biased. Previous studies have revealed inconsistent results complicating a sound interpretation of these findings. In the present study, we summarized the existing literature through a systematic search of articles. Meta-analyses were used to evaluate effect sizes of instructed downregulation strategies on common autonomic (electrodermal, respiratory, cardiovascular, and pupillometric) and electromyographic (corrugator activity, emotion-modulated startle) measures. Moderator analyses were conducted, with moderators including study design, emotion induction, control instruction and trial duration. We identified k = 78 studies each contributing multiple sub-samples and performed 23 meta-analyses for combinations of emotion regulation strategy and psychophysiological measure. Overall, results showed that effects of reappraisal and suppression on autonomic measures were highly inconsistent across studies with rather small mean effect sizes. Electromyography (startle and corrugator activity) showed medium effect sizes that were consistent across studies. Our findings highlight the diversity as well as the low level of standardization and comparability of research in this area. Significant moderation of effects by study design, trial duration, and control condition emphasizes the need for better standardization of methods. In addition, the small mean effect sizes resulting from our analyses on autonomic measures should be interpreted with caution. Findings corroborate the importance of multi-channel approaches.

14,144 views
66 citations
Illustration of the Go/NoGo paradigm in this study. To counterbalance the Go and NoGo stimuli across subjects, the first half of low trait anxiety (LTA) and high trait anxiety (HTA) subjects was assigned to program (A), while the second half was assigned to program (B). LTA, the low-trait anxiety group; HTA, the high-trait anxiety group.
Original Research
10 March 2020
Trait Anxiety Attenuates Response Inhibition: Evidence From an ERP Study Using the Go/NoGo Task
Lisheng Xia
3 more and 
Dandan Zhang

Neuropsychology and cognitive neuroscience have shown that anxious individuals have deficits in response inhibition. However, existing knowledge about the influence of trait anxiety on response inhibition is still inconsistent. The aim of this study was to investigate response inhibition between groups with high trait anxiety (HTA) and low trait anxiety (LTA). Here, we used event-related potential (ERP) indexes as biomarkers to examine the effect of trait anxiety on response inhibition using the Go/NoGo task. Behavioral results indicated that the HTA group made significantly lower accuracy than did the LTA group in the NoGo condition but not the Go condition. Meanwhile, the HTA group needed significantly longer overall response time (RT) than the LTA group did. ERP analyses revealed that the HTA group had smaller and later frontal NoGo-N2 as well as larger and later parietal NoGo-P3 compared to the LTA group. The two response inhibition-related ERP components are distinct neurophysiological indexes that, first, the NoGo-N2 is a component involved in the motor plan prior to the motor execution inhibitory process. Second, the NoGo-P3 reflects later monitoring and evaluation of the inhibition process. Accordingly, the current ERP findings suggest that HTA individuals’ response inhibition deficits are the consequence of abnormal premotor inhibition control and inefficient evaluation and monitoring. In addition, we also found that the peak amplitude of NoGo-N2 and NoGo-P3 were significantly correlated with the State–Trait Anxiety Inventory (STAI) scores after correction for multiple comparisons. To sum up, these results support the notion that trait anxious individuals have response inhibition deficits in the Go/NoGo task.

10,176 views
34 citations
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