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Mean effect sizes and confidence intervals for each conducted meta-analysis (upper panel) sorted by number of samples k of the meta-analysis, respectively (lower panel). Suppr, suppression; reappr, reappraisal; distr, distraction; HR, heart rate; SCL, skin conductance level; SCR, skin conductance response; FT, finger temperature; cEMG, corrugator activity; FPA, finger pulse amplitude; FPTT, finger pulse transit time; RA, respiration amplitude; HRV, heart rate variability; PD, pupil dilation; DBP, diastolic blood pressure; SBP, systolic blood pressure; EPTT, ear pulse transit time; MAP, mean arterial pressure.
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Behavioral results. (A) The Go accuracy and NoGo accuracy in the two groups. (B) The overall response time (RT) in the two groups. Bars represent standard error of the mean. LTA, the low-trait anxiety group; HTA, the high-trait anxiety group. *p < 0.05.
Original Research
10 March 2020

Neuropsychology and cognitive neuroscience have shown that anxious individuals have deficits in response inhibition. However, existing knowledge about the influence of trait anxiety on response inhibition is still inconsistent. The aim of this study was to investigate response inhibition between groups with high trait anxiety (HTA) and low trait anxiety (LTA). Here, we used event-related potential (ERP) indexes as biomarkers to examine the effect of trait anxiety on response inhibition using the Go/NoGo task. Behavioral results indicated that the HTA group made significantly lower accuracy than did the LTA group in the NoGo condition but not the Go condition. Meanwhile, the HTA group needed significantly longer overall response time (RT) than the LTA group did. ERP analyses revealed that the HTA group had smaller and later frontal NoGo-N2 as well as larger and later parietal NoGo-P3 compared to the LTA group. The two response inhibition-related ERP components are distinct neurophysiological indexes that, first, the NoGo-N2 is a component involved in the motor plan prior to the motor execution inhibitory process. Second, the NoGo-P3 reflects later monitoring and evaluation of the inhibition process. Accordingly, the current ERP findings suggest that HTA individuals’ response inhibition deficits are the consequence of abnormal premotor inhibition control and inefficient evaluation and monitoring. In addition, we also found that the peak amplitude of NoGo-N2 and NoGo-P3 were significantly correlated with the State–Trait Anxiety Inventory (STAI) scores after correction for multiple comparisons. To sum up, these results support the notion that trait anxious individuals have response inhibition deficits in the Go/NoGo task.

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