Bacterial Vaginosis, a Model of True Polymicrobial Infections: Genetics, Evolution, Clinical and Socio-Clinical Implications

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Alexander Swidsinski

Charité University Medicine Berlin

Mario Vaneechoutte

Ghent University

University of Minho

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Infections are traditionally regarded as mono-pathogenic. This attitude hampers our understanding of polymicrobial processes. Due to cooperation, polymicrobials demonstrate properties different to each of the participating species, deliberately colonize surfaces in a hostile environment, and act similarly to true multicellular organisms. Bacterial vaginosis (BV) is a remarkable example of that. Clue cells from vaginal secretions of women with bacterial vaginosis are covered with a prolific polymicrobial biofilm. While none of the involved microbial species are able to cause a disease on their own, the established polymicrobial BV-biofilm is extremely stable, drug resistant, growing and being transfected per continuum.

The aim of the proposed topic is to reveal the secrets of bacterial vaginosis; such as biofilm formation, propagation, transfection, and clinical implications.

Infections are traditionally regarded as mono-pathogenic. This attitude hampers our understanding of polymicrobial processes. Due to cooperation, polymicrobials demonstrate properties different to each of the participating species, deliberately colonize surfaces in a hostile environment, and act similarly to true multicellular organisms. Bacterial vaginosis (BV) is a remarkable example of that. Clue cells from vaginal secretions of women with bacterial vaginosis are covered with a prolific polymicrobial biofilm. While none of the involved microbial species are able to cause a disease on their own, the established polymicrobial BV-biofilm is extremely stable, drug resistant, growing and being transfected per continuum.

The aim of the proposed topic is to reveal the secrets of bacterial vaginosis; such as biofilm formation, propagation, transfection, and clinical implications.

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Editors

Alexander Swidsinski

Charité University Medicine Berlin

Mario Vaneechoutte

Ghent University

University of Minho

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Frontiers in Cellular and Infection Microbiology

Clinical Microbiology, Molecular Bacterial Pathogenesis, Microbiome in Health and Disease

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Frontiers in Microbiology

Microbial Physiology and Metabolism

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