The regulated secretory pathway in neuroendocrine cells

184.2K

views

60

authors

18

articles

The regulated secretory pathway in neuroendocrine cells

184.2K

views

60

authors

18

articles

Editorial

08 April 2014

The Regulated Secretory Pathway in Neuroendocrine Cells

Rafael Vazquez-Martinez

and

Stéphane Gasman

7,159 views

7 citations

Editors

2

Rafael Vazquez-Martinez

Maimonides Biomedical Research Institute of Cordoba (IMIBIC)

Stephane Gasman

Institut des Neurosciences Cellulaires et Intégratives, Faculté des Sciences de la Vie, Université de Strasbourg

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The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, posttranslational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins
participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides.

The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, posttranslational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins
participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides.

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Editors

Rafael Vazquez-Martinez

Maimonides Biomedical Research Institute of Cordoba (IMIBIC)

Stephane Gasman

Institut des Neurosciences Cellulaires et Intégratives, Faculté des Sciences de la Vie, Université de Strasbourg

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184,217 Total views

142,146 Article views

36,001 Article downloads

6,070 Topic views

Published In

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Frontiers in Endocrinology

Neuroendocrine Science

Journal Thumbnail

Frontiers in Neuroscience

Neuroendocrine Science

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