About this Research Topic
In the context of inflammation, the (Fc) fragment domain of IgGs can trigger pro- or anti-inflammatory responses. Numerous studies provided evidence that carbohydrates attached to the IgG Fc domain are essential for IgG function. The pro- or anti-inflammatory effector function of IgGs is mediated by different affinities for activating FcγRs (FcγRI, RIIa, RIIIa and RIIIb) and inhibiting FcγRIIb expressed by immune cells. A high level of sialylation of the IgG Fc fragment decreases ADCC potential through low affinity for activating receptors. Conversely, bisecting N-acetylglucosamines on the Fc fragment are pro-inflammatory and enhance ADCC. Different murine models have confirmed that the anti-inflammatory activity of intra-venous IgGs is due to their sialylated Fc fragments.
In autoimmune diseases, such as rheumatoid arthritis, patients show low levels of IgG Fc sialylation. During pregnancy, increased IgG sialylation is associated with remission of rheumatoid arthritis. In alloimmunity, anti-HLA donor specific antibodies are associated with reduced long-term transplant function and an increase in the prevalence of chronic rejection, whereas others do not. The glycosylation level of Igs may explain their “non-aggressive” and/or “protective” action. Similarly, the glycosylation of IgA1s plays an important role in IgA nephropathy. In this disease, circulating IgA1s are deficient in galactose and are not correctly cleared by anti-IgA1 antibodies conducing to glomerular lesions.
The targets of Igs are also of increasing interest in human pathology, and important antigenic drivers are being discovered in the context of monoclonal gammopathies of undetermined significance (MGUS) and multiple myeloma (MM). Lyso-glucosylceramide 1 (LGL1) and lyso-phosphatidylcholine (LPC), and several infectious pathogens, including Epstein-Barr virus and hepatitis C virus, were recently shown to be the targets of monoclonal IgGs in MGUS and MM. Monoclonal IgGs bear very lowly sialylated glycans, which suggests a pro-inflammatory state, reinforcing the notion that chronic antigenic stimulation and an abnormal immune response contribute to the pathogenesis of MGUS and MM.
This Research Topic aims to provide up-to-date knowledge on differences in structure, isotype, targets and post-translational modifications of immunoglobulins and their consequences in specific pathological contexts, especially infection, inflammation and autoimmunity.
We welcome the submission of Reviews, Mini-Reviews, Original Research articles, Technology Reports and Method articles covering the following sub-topics:
1) The role of Ig structures and isotypes in human disease.
2) The targets of Igs and their role in human pathology, including cancer.
3) The role of Ig glycosylation and other post-translational modifications in human disease.
Keywords: Immunoglobulins, Glycosylation, Targets, Inflammation, Infection
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.