Combating Antimicrobial Resistance - A One Health Approach

258.6K

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178

authors

26

articles

Combating Antimicrobial Resistance - A One Health Approach

258.6K

views

178

authors

26

articles

Editorial

22 January 2020

Editorial: Combating Antimicrobial Resistance - A One Health Approach

Ghassan M. Matar

,

Antoine Andremont

and

Wael Bazzi

7,705 views

10 citations

Editors

2

Ghassan M Matar

American University of Beirut

Antoine Andremont

Université Paris Cité

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The articles published in this Research Topic will focus on understanding the mechanisms of resistance in Gram-negative multi-drug resistant (MDR) strains, and will also address combination antimicrobial therapy as a potential treatment against Gram-negative bacilli. The discovery of novel antibiotics will also be covered.

Antimicrobial resistance is a life threatening, urgent global health problem. There is increasing concern regarding the alarming emergence of MDR superbugs. Infections resulting from such pathogens are barely responsive to treatment with few, if any, antibiotics currently available; reviving memories of the pre-antibiotic era and raising concerns regarding a post-antibiotic era.

Given the complexity of the antimicrobial resistance challenge at the interface of human and animal health, combined with the impact on the environment, it seems particularly important to emphasize the role of a One Health approach in addressing the problem. Unifying efforts to combat and overcome this hurdle requires a multifaceted approach. The cornerstones of this task are the understanding of resistance mechanisms, the utilization of combination therapy for potential therapeutic options, and the discovery of novel antibiotics and/or targets.

The findings of studies submitted to this Research Topic must reflect an understanding of the mechanisms of resistance in Gram-negative pathogens, the use of combination therapy to treat complicated MDR infections, or the discovery of novel antibiotics with potential novel targets or new mode of actions.

The articles published in this Research Topic will focus on understanding the mechanisms of resistance in Gram-negative multi-drug resistant (MDR) strains, and will also address combination antimicrobial therapy as a potential treatment against Gram-negative bacilli. The discovery of novel antibiotics will also be covered.

Antimicrobial resistance is a life threatening, urgent global health problem. There is increasing concern regarding the alarming emergence of MDR superbugs. Infections resulting from such pathogens are barely responsive to treatment with few, if any, antibiotics currently available; reviving memories of the pre-antibiotic era and raising concerns regarding a post-antibiotic era.

Given the complexity of the antimicrobial resistance challenge at the interface of human and animal health, combined with the impact on the environment, it seems particularly important to emphasize the role of a One Health approach in addressing the problem. Unifying efforts to combat and overcome this hurdle requires a multifaceted approach. The cornerstones of this task are the understanding of resistance mechanisms, the utilization of combination therapy for potential therapeutic options, and the discovery of novel antibiotics and/or targets.

The findings of studies submitted to this Research Topic must reflect an understanding of the mechanisms of resistance in Gram-negative pathogens, the use of combination therapy to treat complicated MDR infections, or the discovery of novel antibiotics with potential novel targets or new mode of actions.

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Editors

Ghassan M Matar

American University of Beirut

Antoine Andremont

Université Paris Cité

Impact

258,582 Total views

202,965 Article views

50,513 Article downloads

5,104 Topic views

Published In

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Frontiers in Cellular and Infection Microbiology

Clinical Microbiology

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Frontiers in Microbiology

Antimicrobials, Resistance and Chemotherapy

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