The Harm of Medication: From Early Identification to Prevention

53.1K
views
97
authors
8
articles
Cover image for research topic "The Harm of Medication: From Early Identification to Prevention"
Editors
4
Impact
Loading...
(A) Hapten/pro-hapten concept: Drugs or reactive metabolites serve as haptens and bind to the endogenous peptides to form the haptenated peptides (neo-epitopes) that presented by HLA molecules at the cell surface where the novel peptide is recognized as foreign. The HLA/drug/peptide complex is recognized by TCR, which trigger the drug-specific T cell activation. (B) The “pharmacological interaction with immune receptors (p-i)” concept: T cells are proposed to recognize immunogenic complexes formed through a labile interaction of the causative drug, HLA and TCR at the cell surface or TCR and active drug-specific T cells without the intercellular processing in APC. (C) The altered repertoire model: The drug interacts with the antigen-binding cleft of the HLA molecule altering the space available to anchor residues of peptide ligands and results in selection of ligands with a novel HLA binding motif, which promotes polyclonal T-cell activation. (D) The “altered TCR repertoire” model. Drugs bind to TCR, resulting in conformational change of TCR, which then bind to the HLA/self-peptide complex to elicit immune reaction.
10,941 views
45 citations
7,778 views
19 citations
5,464 views
28 citations
Recommended Research Topics
Frontiers Logo

Frontiers in Pharmacology

Artificial Intelligence for Translational Pharmacology
Edited by Zhi-Liang Ji, Lixia Yao, Kartick Chandra Pramanik, Zhaohui John Cai
61.4K
views
64
authors
10
articles
Frontiers Logo

Frontiers in Pharmacology

Cognitive Impairment: Therapy Momentum in the Continuum of Life
Edited by Artemissia-Phoebe Nifli, Magda Tsolaki, Jos Tournoy, Kazuki Ide
61.1K
views
32
authors
6
articles
Frontiers Logo

Frontiers in Pharmacology

Women in Translational Pharmacology: 2021
Edited by Valentina Vengeliene, Lu Qin
28.1K
views
38
authors
6
articles
Frontiers Logo

Frontiers in Pharmacology

Pharmacoinformatics: New developments and challenges in drug design
Edited by David Ramírez, José L Medina-Franco, Rafael Peláez, Carlos F. Lagos
32.1K
views
59
authors
11
articles
Frontiers Logo

Frontiers in Pharmacology

Pharmacoepidemiology and pharmacovigilance post-marketing drug safety studies
Edited by Yusuf Karatas, Maria Auxiliadora Parreiras Martins, Ahmet AKICI, Nafees Ahmad
59.7K
views
110
authors
17
articles