Axon Neurobiology: Fine-Scale Dynamics of Microstructure and Function

163.3K

views

69

authors

20

articles

Axon Neurobiology: Fine-Scale Dynamics of Microstructure and Function

163.3K

views

69

authors

20

articles

Editorial

23 September 2020

Editorial: Axon Neurobiology: Fine-Scale Dynamics of Microstructure and Function

Haruyuki Kamiya

and

Dominique Debanne

2,979 views

1 citations

Editors

2

Haruyuki Kamiya

Graduate School of Medicine, Hokkaido University

Dominique Debanne

Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS)

Impact

Fetching...

About

The axon represents the main output structure of neurons. It carries neuronal information under the form of action potentials from the site of initiation at the axon initial segment (AIS) to the terminal located in some cases at several centimeters without attenuation. Comprehensive understanding of axon neurobiology, from molecule to theory, is a critical step towards understanding logic of signal processing in the brain. Several aspects of axon neurobiology is envisaged from AIS organization & development to structural and functional plasticity through control of axonal propagation. Despite the difficulty in the analysis of axon physiology due to the small size of the axon, recent methodological advance enabled analysis of the structure and function of axons on a fine scale.

In this Research Topic, we will highlight recent progress in axon research from various experimental approaches. These will include subcellular patch-clamp recording from axons or axon terminals, computational simulation based on realistic axon model, voltage- and calcium-imaging, molecular biology, cell biology and super resolution confocal imaging. We aimed to shed light on the fact that CNS axons are regulated much dynamically than previously thought. Any type of contribution, including original research, review, and perspective on this topic is welcome.

The axon represents the main output structure of neurons. It carries neuronal information under the form of action potentials from the site of initiation at the axon initial segment (AIS) to the terminal located in some cases at several centimeters without attenuation. Comprehensive understanding of axon neurobiology, from molecule to theory, is a critical step towards understanding logic of signal processing in the brain. Several aspects of axon neurobiology is envisaged from AIS organization & development to structural and functional plasticity through control of axonal propagation. Despite the difficulty in the analysis of axon physiology due to the small size of the axon, recent methodological advance enabled analysis of the structure and function of axons on a fine scale.

In this Research Topic, we will highlight recent progress in axon research from various experimental approaches. These will include subcellular patch-clamp recording from axons or axon terminals, computational simulation based on realistic axon model, voltage- and calcium-imaging, molecular biology, cell biology and super resolution confocal imaging. We aimed to shed light on the fact that CNS axons are regulated much dynamically than previously thought. Any type of contribution, including original research, review, and perspective on this topic is welcome.

Download ebook

Share

Editors

Haruyuki Kamiya

Graduate School of Medicine, Hokkaido University

Dominique Debanne

Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS)

Impact

163,304 Total views

121,942 Article views

27,294 Article downloads

14,068 Topic views

Published In

Journal Thumbnail

Frontiers in Cellular Neuroscience

Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic