Organoids as Model Systems for Human Development, Disease and Clinical Applications

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Eumorphia Remboutsika

University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens

Thimios Mitsiadis

University of Zurich

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Appropriate systems for modeling human organs and pathologies represent a constant need in all branches of biomedical research and practice. Ttranslation of preclinical results into effective treatments remains poor, highlighting the need for accurate tissue-specific human emulation systems. In this context, great expectations are accompanying the recent developments on organoids.

Organoids are three dimensional tissue structures assembled from pluripotent or adult organ-specific stem cells. Their structure allows establishment of complex cell-cell interactions and gradients of oxygen, nutrients and soluble signals that generate tissue-specific heterogeneous cell types. Organoids are increasingly used to model and understand human organ-specific physiology in both normal and pathological conditions. As such, they emerge as powerful tools for personalised and precision medicine.

This Research Topic on “Organoids as Model Systems for Human Development, Disease and Clinical Applications” solicits original research articles, review articles, commentaries and perspectives from all areas of Stem Cell Biology and Organoid Research, including, but not limited to, pluripotent cell-derived organoids, tumour-derived tissue-specific organoids, organoids as disease models, organoids for drug testing, tissue engineering approaches, mathematical models, and tissue regeneration.

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Editors

Eumorphia Remboutsika

University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens

Thimios Mitsiadis

University of Zurich

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Published In

Frontiers in Physiology

Craniofacial Biology and Dental Research

Frontiers in Genetics

Stem Cell Research

Frontiers in Cell and Developmental Biology

Stem Cell Research

Frontiers in Oncology

Stem Cell Research

Frontiers in Bioengineering and Biotechnology

Stem Cell Research

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