Aging and Neurodegeneration: Therapeutic Approaches via Sirtuins

Editors

Gizem Donmez

Adnan Menderes University

Impact

Bona fide and suggested SIRT3 substrates.

Review

06 September 2013

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

Brad Kincaid

and

Ella Bossy-Wetzel

56,850 views

279 citations

Anti-inflammatory mechanisms of SIRT1. SIRT1 deacetylates p65 and blocks the transactivation of NF-κB-dependent gene expression. SIRT1 suppresses the activity of PARP-1, a coactivator of NF-κB-dependent transcription, by deacetylation and by inhibiting its expression. PARP-1 activation could deplete NAD+, resulting in inhibition of SIRT1 and NF-κB activation. On the epigenetic level, SIRT1 represses NF-κB-dependent inflammatory gene expression by deacetylating H4K16 and also by recruiting more components of repressor complexes. SIRT1 deacetylates and activates histone methyltransferase SUV39H1, which suppresses expression of inducible inflammatory genes. DNA methylation is associated with suppressed expression. Whether SIRT1 could inhibit expression of inflammatory genes by enhancing promoter methylation remains to be determined.

Review

25 September 2013

Sirtuins in neurodegenerative diseases: an update on potential mechanisms

Sang-Won Min

, 3 more and

Li Gan

17,276 views

107 citations

Schematic overview of molecular targets of SIRT3 and the role in regulating metabolism in mitochondria.

Review

23 July 2013

Sirtuins: from metabolic regulation to brain aging

Wenzhen Duan

17,359 views

77 citations

Mini Review

09 April 2013

The role of sirtuins in Alzheimer's disease

Rakhee Lalla

and

Gizem Donmez

8,597 views

63 citations

Original Research

11 August 2014

SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway

Lei Liu

, 3 more and

Gizem Donmez

7,624 views

56 citations

Original Research

05 December 2012

Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory

Onder Albayram

, 1 more and

Andreas Zimmer

6,928 views

26 citations

Review

13 June 2013

Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence

Frédéric Parmentier

, 1 more and

Christian Neri

7,414 views

10 citations

Open for submission

Frontiers in Aging Neuroscience

Impact of Aging on Small Molecule Transport Across the Blood-Brain Barrier in Neurodegenerative Disorders

Edited by Sirajunnisa Abdul Razack, Thomson Patrick Joseph, Manigandan Venkatesan

Deadline

10 January 2025

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