About this Research Topic
Recently, Hee-Seung Lee introduced the term “foldectures” to indicate a supramolecular assembly (architecture) “with unprecedented topological complexity derived from the rapid and nonequilibrium aqueous phase self-assembly of foldamers.” In theory, foldectures might be designed to mimic biological architectures, including protein quaternary structures or even more complex assemblies like virus capsids or globular proteins.
It is clear that the cutting-edge field of foldamers and foldectures will reveal futuristic applications that may lead to new paradigms in medicinal chemistry and drug design.
As such, this Research Topic welcomes articles dealing with:
a) Synthesis of new non-natural amino acids or nucleotides able to induce a particular secondary structure when included in a peptide or nucleic acid chain
b) Synthesis and/or structural characterization of new foldectures
c) Computational studies on foldamers/foldectures
d) New applications of foldamers or foldectures to modulate biological functions, including (but not limited to):
1. Modulation of protein-protein, protein-nucleic acid, or nucleic acid-nucleic acid interactions
2. Interference of foldamers with pathogens
3. Use of foldamers or foldectures for diagnostics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.