The discovery (identification) of sortilin at the end of the 90s from three different laboratories using three different biochemical approaches already predicted multifunctional roles of the protein. Therefore, growing evidence for the ability of sortilin to exert important functions as a receptor, a co-receptor and a sorting protein to plasma membrane and or to lysosomes, have been described. In addition, modifications of its expression allowed to determine that sortilin displays a crucial role in numerous pathophysiological functions from central and peripheral organs. The central role of sortilin has been observed in Alzheimer and Parkinson diseases, in depression as well as in the regulation of lipidomia and glucose homeostasis whose dysfunctions lead to cardiovascular risks.
The present Research Topic aims to collect original research studies as well as review and perspective articles that provide advances and future directions in the physiology and the pathologies regulated by sortilin and its associated proteins, receptors and channels.
Articles or reviews should not be restricted to central pathologies (frontotemporal dementia, Alzheimer, Parkinson, depression, etc.) but may also concern peripheral pathologies (diabetes, cardiovascular diseases, …). Authors may feel free to choose another theme that fits the purpose of this Research Topic.
We would like that this Research Topic on Sortilin and Sortilin Partners in Pathologies in Pharmacology becomes a major reference for those working in the field. All manuscripts will thus be peer-reviewed and only papers that meet our standards will appear in this Research Topic.
The discovery (identification) of sortilin at the end of the 90s from three different laboratories using three different biochemical approaches already predicted multifunctional roles of the protein. Therefore, growing evidence for the ability of sortilin to exert important functions as a receptor, a co-receptor and a sorting protein to plasma membrane and or to lysosomes, have been described. In addition, modifications of its expression allowed to determine that sortilin displays a crucial role in numerous pathophysiological functions from central and peripheral organs. The central role of sortilin has been observed in Alzheimer and Parkinson diseases, in depression as well as in the regulation of lipidomia and glucose homeostasis whose dysfunctions lead to cardiovascular risks.
The present Research Topic aims to collect original research studies as well as review and perspective articles that provide advances and future directions in the physiology and the pathologies regulated by sortilin and its associated proteins, receptors and channels.
Articles or reviews should not be restricted to central pathologies (frontotemporal dementia, Alzheimer, Parkinson, depression, etc.) but may also concern peripheral pathologies (diabetes, cardiovascular diseases, …). Authors may feel free to choose another theme that fits the purpose of this Research Topic.
We would like that this Research Topic on Sortilin and Sortilin Partners in Pathologies in Pharmacology becomes a major reference for those working in the field. All manuscripts will thus be peer-reviewed and only papers that meet our standards will appear in this Research Topic.
