About this Research Topic
The aim of this Research Topic is to collate primary articles, reviews and opinion pieces on the complex reciprocal relationships between the immune system, tumors and the tumour microenvironment, and the stimulatory and suppressive effects of radiotherapy on innate and adaptive immunity in the pre-clinical and clinical settings.
Findings that contribute to a better understanding of the scheduling, dosing, fractionating and timing of radiation and its combination with immunotherapies, and provide insight into approaches for predicting and monitoring responsiveness are welcome. Submissions relating to the nature and effectiveness of combining ionizing radiation with immunotherapies such as immune checkpoint inhibitors, agents counteracting the immunsuppressive tumour microenvironment, antibody therapies, vaccination, immune cell therapies, engineered CAR T/NK cells, hyperthermia, and the clinical challenges that are presented are also encouraged.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.