SIRT family in Endocrinology

Silent information regulator 1 (SIRT), also known as NAD-dependent deacetylase sirtuin, is a member of the class III group of histone deacetylases, collectively called sirtuins. The mammalian sirtuin family consists of 7 members, designated SIRT1 through SIRT7, which are characterized by a conserved 275-amino-acid catalytic core and unique additional N-terminal and C-terminal sequences of variable length. Previous studies have shown that SIRT can deacetylate many transcription factors, including forkhead box O (FOXO) transcription factors, p53, nuclear factor-κB (NF-κB), liver X receptor (LXR), and nuclear co-activators, as well, including peroxisome proliferator-activated receptor γcoactivator-1α(PGC-1α), cAMP-responsive element-binding protein–regulated transcription co-activator 2, and period homolog 2. It has been reported that SIRT family perform a wide variety of functions in a variety of biological systems, including obesity-associated metabolic diseases, endocrine disease, cancer, aging, cellular senescence, and oxidative stress, prion-mediated neurodegeneration, inflammation, and placental cell survival. Moreover, recent studies have demonstrated that SIRT play a pivotal roles in bone metabolism, cardiovascular diseases, diabetes, cancer, and neurological diseases.

We would like to collect potential articles involving Diabetes and Obesity, Cardiovascular endocrinology, Cellular endocrinology, Experimental Endocrinology, Molecular and Structural Endocrinology, Neuroendocrinology, Pediatric Endocrinology, Thyroid Endocrinology, et al. The main types of submitted manuscripts shall be Original Articles and Reviews. However, mini-review, meta-analysis, commentaries and other types are also welcomed.

This Research Topic will solicit original research articles, reviews, systematic review and meta-analysis, commentaries, etc that cover the themes of diabetes, thyroid diseases, cardiovascular metabolism, cancer endocrinology, bone metabolism.