About this Research Topic
The impressive clinical response achieved in some cancer patients treated with novel immunotherapeutic drugs, such as the immune check point inhibitors, has enforced the idea that the immune system plays a crucial roles in cancer surveillance, prevention and elimination. Several studies have revealed that the cancer chemopreventive properties of certain dietary phytochemicals may be associated with their ability to modulate immune responses. In addition, accumulating evidences suggest that clinically-validated cancer chemopreventive agents such as aspirin, COX-2 inhibitors, tamoxifen and bisphosphonates may exert their effects, at least in part, by promoting immunosurveillance.
This Research Topic will highlight recent advances on the endogenous modulation of immune system for cancer chemoprevention. We welcome the submission of Original Research articles encompassing both preclinical and clinical studies, as well as Review and Opinion articles that include, but are not limited to, the following aspects:
1. Dietary phytochemicals and immunomodulation.
2. Effects of cyclooxigenase-2 inhibition on immune cells.
3. The impact of bisphosphonates on immune regulation.
4. Modulation of immune cell function by tamoxifen.
5. Naturally occurring or synthetic drugs capable of strengthen endogenous anti-tumor immune responses.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.