Pregnancy complications such as preeclampsia, fetal growth restriction (FGR), gestational diabetes, and hypertensive disorders are significant contributors to maternal and fetal morbidity and mortality. These conditions often stem from placental dysfunction, where disrupted endocrine and metabolic signaling can impair maternal-fetal communication and result in poor pregnancy outcomes. The placenta acts as the main bridge between mother and fetus, managing the exchange of nutrients and oxygen while also being vital for hormone production and immune system regulation.
This research topic will explore the metabolic, endocrine, and molecular mechanisms underlying placental dysfunction and maternal-fetal health in pregnancy complications.
This Research Topic welcomes submissions focused on, but not limited to, the following subtopics:
• Investigating how oxidative stress contributes to placental insufficiency in preeclampsia, FGR, and gestational diabetes.
• Exploring the role of lipid dysregulation, including ceramide metabolism, in placental function and its effects on pregnancy outcomes.
• Understanding the mechanisms of ferroptosis and other regulated cell death pathways.
• Examining how placental extracellular vesicles mediate signaling between the placenta and maternal tissues, and their role in pregnancy complications.
• Assessing how endocrine changes in gestational diabetes and hypertensive disorders alter placental function and fetal development.
• Identifying novel biomarkers that can aid in early diagnosis of conditions such as preeclampsia and FGR.
• Developing new therapies focused on restoring placental function, including targeting oxidative stress and lipid metabolism
Pregnancy complications such as preeclampsia, fetal growth restriction (FGR), gestational diabetes, and hypertensive disorders are significant contributors to maternal and fetal morbidity and mortality. These conditions often stem from placental dysfunction, where disrupted endocrine and metabolic signaling can impair maternal-fetal communication and result in poor pregnancy outcomes. The placenta acts as the main bridge between mother and fetus, managing the exchange of nutrients and oxygen while also being vital for hormone production and immune system regulation.
This research topic will explore the metabolic, endocrine, and molecular mechanisms underlying placental dysfunction and maternal-fetal health in pregnancy complications.
This Research Topic welcomes submissions focused on, but not limited to, the following subtopics:
• Investigating how oxidative stress contributes to placental insufficiency in preeclampsia, FGR, and gestational diabetes.
• Exploring the role of lipid dysregulation, including ceramide metabolism, in placental function and its effects on pregnancy outcomes.
• Understanding the mechanisms of ferroptosis and other regulated cell death pathways.
• Examining how placental extracellular vesicles mediate signaling between the placenta and maternal tissues, and their role in pregnancy complications.
• Assessing how endocrine changes in gestational diabetes and hypertensive disorders alter placental function and fetal development.
• Identifying novel biomarkers that can aid in early diagnosis of conditions such as preeclampsia and FGR.
• Developing new therapies focused on restoring placental function, including targeting oxidative stress and lipid metabolism