About this Research Topic
Extracellular vesicles (EVs), especially the smaller exosomal types, have emerged as pivotal players in systemic intercellular communication. Their ability to transport a diverse array of molecules —from lipids, proteins, and various RNA forms to other genetic materials— enables them to modulate recipient cells even at considerable distances from their point of origin. This capability positions EVs as potential key agents in reprogramming cells involved in various pathological conditions, including allergic diseases. With allergies becoming increasingly prevalent, understanding how EVs influence immune responses and allergic reactions has become imperative for the development of novel therapeutic strategies.
While omalizumab has shown efficacy for many CU patients, resistance to this treatment has brought attention to the need for further research into the underlying factors driving treatment resistance. Investigating additional management options is crucial, especially for patients who do not respond to existing therapies. Special populations with CU—including children, elderly individuals, pregnant women, and those who are lactating—pose unique challenges that call for focused strategies to improve care and outcomes. Moreover, exploring therapies that go beyond IgE-targeted treatments, such as antihistamines and omalizumab, offers promising new pathways in expanding the options available for CU management.
This Research Topic is dedicated to exploring the functions of EVs within the context of allergic diseases, both from immunological and therapeutic perspectives. The objectives include investigating how EVs regulate allergic manifestations and how they can be harnessed to induce immunological tolerance and deliver innovative immunotherapies for allergy treatment. Such studies are crucial as they have the potential to revolutionize the management of allergies through advanced biotechnological interventions.
We aim to cover a comprehensive range of studies concerning EVs in allergies, focusing on their roles in intercellular signaling and immune modulation:
- Investigating the mechanisms by which EVs facilitate cellular communication relevant to allergic responses
- Exploring how EVs can mediate immune reactions in allergic conditions
- Evaluating the therapeutic potential of EVs in allergen-specific immunotherapy
We welcome submissions on, but not limited to, the following themes:
- The role of EVs in regulating intercellular messaging during allergic reactions
- Detailed studies of EV-mediated modifications in immune cell functions in allergies
- Clinical trials and case studies that demonstrate the efficacy of EV-based therapies in allergy treatment
Through this topic, we aim to deepen the understanding of EVs' capabilities and explore their full potential in managing and curing allergic diseases, paving the way for innovative, effective treatments that could significantly alleviate the burden of allergies on patients worldwide.
While omalizumab has shown efficacy for many CU patients, resistance to this treatment has brought attention to the need for further research into the underlying factors driving treatment resistance. Investigating additional management options is crucial, especially for patients who do not respond to existing therapies. Special populations with CU—including children, elderly individuals, pregnant women, and those who are lactating—pose unique challenges that call for focused strategies to improve care and outcomes. Moreover, exploring therapies that go beyond IgE-targeted treatments, such as antihistamines and omalizumab, offers promising new pathways in expanding the options available for CU management.
This Research Topic is dedicated to exploring the functions of EVs within the context of allergic diseases, both from immunological and therapeutic perspectives. The objectives include investigating how EVs regulate allergic manifestations and how they can be harnessed to induce immunological tolerance and deliver innovative immunotherapies for allergy treatment. Such studies are crucial as they have the potential to revolutionize the management of allergies through advanced biotechnological interventions.
We aim to cover a comprehensive range of studies concerning EVs in allergies, focusing on their roles in intercellular signaling and immune modulation:
- Investigating the mechanisms by which EVs facilitate cellular communication relevant to allergic responses
- Exploring how EVs can mediate immune reactions in allergic conditions
- Evaluating the therapeutic potential of EVs in allergen-specific immunotherapy
We welcome submissions on, but not limited to, the following themes:
- The role of EVs in regulating intercellular messaging during allergic reactions
- Detailed studies of EV-mediated modifications in immune cell functions in allergies
- Clinical trials and case studies that demonstrate the efficacy of EV-based therapies in allergy treatment
Through this topic, we aim to deepen the understanding of EVs' capabilities and explore their full potential in managing and curing allergic diseases, paving the way for innovative, effective treatments that could significantly alleviate the burden of allergies on patients worldwide.
Keywords: Extracellular vesicles, Exosomes, Immune modulation, Intercellular communication, Immunological tolerance, Allergen-specific immunotherapy, EV-mediated immune responses, Biotechnological interventions in allergy, Therapeutic potential of EVs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
