About this Research Topic

Background

Mucosal immunity plays a crucial role in defending the body against pathogens at mucosal surfaces, such as the gastrointestinal and respiratory tracts. Traditional vaccines primarily elicit systemic immune responses, but mucosal vaccines aim to induce both systemic and localized immunity, particularly through the production of secretory IgA. This is essential for neutralizing pathogens at entry points.

Research in this area focuses on enhancing mucosal immune responses through innovative vaccine designs, delivery methods (like oral or intranasal), and the influence of the microbiome. Understanding these mechanisms is vital for developing effective vaccines against emerging infectious diseases, especially those targeting respiratory and gastrointestinal pathogens. Improved mucosal immunity post-vaccination can lead to better protection strategies and reduced disease burden globally.

The primary problem in the field of mucosal immunity after vaccination is the challenge of inducing robust and lasting immune responses at mucosal surfaces. Traditional vaccination strategies often fail to elicit effective mucosal immunity, leaving individuals vulnerable to infections, particularly in respiratory and gastrointestinal tracts.

To tackle this issue, researchers are exploring several strategies. Recent advances include the development of mucosal vaccines using novel delivery systems, such as nanoparticle-based formulations and mucosal adjuvants, which enhance immune responses. Additionally, oral and intranasal vaccines are being optimized to improve uptake and response at mucosal sites.

Investigating the role of the gut microbiome is also gaining attention, as it can influence immune maturation and responses. Furthermore, studying immune memory mechanisms at mucosal sites can help in designing vaccines that provide long-term protection. By integrating these approaches, researchers aim to develop effective mucosal vaccines that can significantly improve immunity against a range of infectious diseases.

We welcome manuscripts focusing on, but not limited to, the following sub-topics:

• Mechanisms of Mucosal Immunity: Understanding the biological processes involved in mucosal immune responses.

• Vaccine Delivery Systems: Innovations in oral, intranasal, and other delivery methods for mucosal vaccines.

• Role of Adjuvants: Investigation of mucosal adjuvants that enhance immune responses.

• Microbiome Influence: The relationship between gut microbiota and mucosal immunity post-vaccination.

• Immunological Memory: Studies on the longevity and robustness of immune memory at mucosal surfaces.

• Clinical Applications: Trials and studies assessing the effectiveness of mucosal vaccines in diverse populations.

• Policy Implications: Reviews on vaccine strategies and public health policies addressing mucosal immunization.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Curriculum, Instruction, and Pedagogy
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Curriculum, Instruction, and Pedagogy
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Mucosal Immunity, Vaccination, Secretory IgA, Mucosal Vaccines, Immune Response, Delivery Systems, Adjuvants, Gut Microbiome, Immunological Memory, Respiratory Infections, Gastrointestinal Pathogens, Clinical Trials, Vaccine Strategies, Systemic Immunity

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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