About this Research Topic
The depth of molecular mechanisms involving DNA dynamics, such as replication, transcription, repair, and maintenance significantly impacts the survival and pathogenic capabilities of microorganisms and parasites. These processes are crucial in maintaining genome integrity, especially given the potential for transcriptional errors and oxidative stress that can lead to genetic damage. Furthermore, the capacity of pathogens to colonize hosts is intricately linked with genome stability through mechanisms like antigenic variation, drug resistance, and immune evasion, which are central to their virulence. Equally, in non-pathogenic organisms, these genetic preservation mechanisms are vital for adapting to various environmental pressures, making this an area rich in both evolutionary and biotechnological significance.
This research topic aims to delve into the molecular intricacies of DNA metabolism that determine the proliferation, adaptability, and success in survival of microorganisms, focusing on both pathogenic and non-pathogenic species. By highlighting the importance of DNA maintenance in response to both natural and hostility-induced conditions, our study seeks to uncover new facets of microbial adaptation and infection mechanisms. This, in turn, can pave the way for novel biotechnological and therapeutic interventions targeting these molecular pathways.
The scope of this research extends to examining the underlying mechanisms that enable microorganisms to manage genomic integrity and adapt to host defenses, which will enhance our understanding of microbial pathogenesis and resilience. To gather further insights, we welcome articles addressing, but not limited to, the following themes:
The interplay between DNA repair processes and microbial adaptability under stress.
Genetic strategies for evading host immune responses and fostering pathogenic virulence.
Role of mutagenesis in the evolutionary trajectories of pathogens.
Applications of understanding DNA mechanisms in designing therapeutic strategies against infectious diseases.
This research topic aims to delve into the molecular intricacies of DNA metabolism that determine the proliferation, adaptability, and success in survival of microorganisms, focusing on both pathogenic and non-pathogenic species. By highlighting the importance of DNA maintenance in response to both natural and hostility-induced conditions, our study seeks to uncover new facets of microbial adaptation and infection mechanisms. This, in turn, can pave the way for novel biotechnological and therapeutic interventions targeting these molecular pathways.
The scope of this research extends to examining the underlying mechanisms that enable microorganisms to manage genomic integrity and adapt to host defenses, which will enhance our understanding of microbial pathogenesis and resilience. To gather further insights, we welcome articles addressing, but not limited to, the following themes:
The interplay between DNA repair processes and microbial adaptability under stress.
Genetic strategies for evading host immune responses and fostering pathogenic virulence.
Role of mutagenesis in the evolutionary trajectories of pathogens.
Applications of understanding DNA mechanisms in designing therapeutic strategies against infectious diseases.
Keywords: DNA mechanisms, microorganisms, pathogenesis, genome stability, pathogen-host relationship, survival strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
