The intricate link between endocrine disorders and cancer development has drawn significant interest, revealing how conditions like insulin resistance and thyroid hormone imbalances contribute to cancer risk and progression beyond their roles in classical endocrine diseases. Meanwhile, the nexus between autoimmune diseases and cancer highlights how systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) foster a tumor-promoting environment through chronic inflammation, immune dysregulation, and metabolic alterations. These conditions amplify tumor malignancy and therapy resistance, with certain autoimmune disorders correlating with increased tumor incidence and distinct cancer types.
This Research Topic aims to elucidate the multifaceted dynamics between endocrine regulation, immune responses, and metabolic pathways within the cancer milieu influenced by autoimmune diseases. It strives to uncover how these interconnected mechanisms drive cancer progression and resist conventional treatments, setting the stage for more tailored and efficacious approaches in precision medicine that enhance disease management and patient outcomes.
To further insights in how metabolic and immune mechanisms interlink with endocrine systems to influence cancer in the context of autoimmune diseases, we welcome articles addressing, but not limited to, the following themes:
o Endocrine Dysregulation and Tumor Progression in Autoimmune Diseases: examining hormonal imbalances and their effects on cancer development.
o Immune-Metabolic Interactions in Cancer Development: studying the roles of chronic inflammation and metabolic disorders in tumor genesis.
o Key Signaling Pathways Linking Autoimmune Diseases, Endocrine Dysfunction, and Cancer: focusing on molecular pathways, including PI3K/AKT/mTOR, JAK/STAT, and AMPK, that bridge immunological, endocrine, and oncological anomalies.
o Chronic Inflammation and Its Interplay with Endocrine and Metabolic Regulation in Cancer: exploring how long-standing inflammation alters the tumor microenvironment.
o Precision Medicine and AI-Driven Approaches Integrating Endocrine and Metabolic Profiles for Autoimmune Disease-Associated Cancers: utilizing AI to enhance precision medicine through complex endocrine and metabolic data analysis.
Keywords: Endocrine Dysregulation, Autoimmune Diseases, Cancer Progression, Immune-Metabolic Interactions, Chronic Inflammation, Signaling Pathways, Precision Medicine, Artificial Intelligence (AI)
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
