About this Research Topic
Immunometabolism, the study of how metabolic pathways interact with immune responses, is a critical and rapidly evolving field. It offers profound insights into the mechanisms that underpin immune tolerance and regulation. The crosstalk between metabolic processes and immune signaling is a crucial determinant of immune cell function, and understanding this relationship is vital for developing new therapeutic strategies for a range of diseases. This research topic seeks to explore the intricate links between metabolism and immunity, focusing on the role of immunometabolism in immune tolerance and regulation. The current challenges lie in the multifactorial influences on immune responses, including drugs, metabolites, microbiota, and nutrition, among other factors, and their complex interactions, which can alter immune cell metabolism and disrupt tolerance. The high heterogeneity among immune cell metabolisms and the delicate balance between immune tolerance and suppression necessitate more extensive and in-depth research to elucidate the intricate relationship between immunometabolism and immune tolerance across various disease spectra and internal environments.
The primary goal of this research topic is to deepen our understanding of immunometabolism's impact on immune tolerance and regulation. By integrating mechanistic studies with clinical research, we aim to identify novel targets for therapeutic intervention and foster the development of personalized medicine approaches.
This collection welcomes submissions that elucidate the molecular and cellular mechanisms of immunometabolism, its role in health and disease, and its potential for clinical application. We value and recognize the importance of your contributions to advancing immunometabolism research. We are particularly interested in studies that provide new insights into metabolic reprogramming in immune cells, the interplay between metabolism and immune signaling, and the therapeutic modulation of these pathways. Authors are encouraged to submit original research that contributes to advancing immunometabolism research and its translation into clinical practice. Subtopics for Further Exploration
1. Metabolic Checkpoints in Immune Cell Activation and Tolerance: Investigating the critical metabolic pathways and enzymes during immune cells’ activation and how they can be modulated to enhance or suppress immune tolerance.
2. Crosstalk Between Metabolism and Immune Signaling: Elucidating the molecular mechanisms by which metabolic intermediates and signaling pathways interact to influence immune cell fate and function.
3. The Impact of Microbiota on Immunometabolism and Tolerance: Exploring the role of gut microbiota in shaping metabolic profiles and immune responses and its implications for immune tolerance and autoimmunity.
4. Nutritional Influences on Immunometabolism: Assessing how dietary components and nutritional status can affect immune cell metabolism and contribute to the maintenance or breakdown of immune tolerance.
5. Targeting Immunometabolism for Immunomodulation Therapy: Identifying novel therapeutic targets within metabolic pathways that can be leveraged to restore or enhance immune tolerance in diseases, including infectious diseases, autoimmune diseases, neoplasms, etc.
The primary goal of this research topic is to deepen our understanding of immunometabolism's impact on immune tolerance and regulation. By integrating mechanistic studies with clinical research, we aim to identify novel targets for therapeutic intervention and foster the development of personalized medicine approaches.
This collection welcomes submissions that elucidate the molecular and cellular mechanisms of immunometabolism, its role in health and disease, and its potential for clinical application. We value and recognize the importance of your contributions to advancing immunometabolism research. We are particularly interested in studies that provide new insights into metabolic reprogramming in immune cells, the interplay between metabolism and immune signaling, and the therapeutic modulation of these pathways. Authors are encouraged to submit original research that contributes to advancing immunometabolism research and its translation into clinical practice. Subtopics for Further Exploration
1. Metabolic Checkpoints in Immune Cell Activation and Tolerance: Investigating the critical metabolic pathways and enzymes during immune cells’ activation and how they can be modulated to enhance or suppress immune tolerance.
2. Crosstalk Between Metabolism and Immune Signaling: Elucidating the molecular mechanisms by which metabolic intermediates and signaling pathways interact to influence immune cell fate and function.
3. The Impact of Microbiota on Immunometabolism and Tolerance: Exploring the role of gut microbiota in shaping metabolic profiles and immune responses and its implications for immune tolerance and autoimmunity.
4. Nutritional Influences on Immunometabolism: Assessing how dietary components and nutritional status can affect immune cell metabolism and contribute to the maintenance or breakdown of immune tolerance.
5. Targeting Immunometabolism for Immunomodulation Therapy: Identifying novel therapeutic targets within metabolic pathways that can be leveraged to restore or enhance immune tolerance in diseases, including infectious diseases, autoimmune diseases, neoplasms, etc.
Keywords: Immunometabolism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
