Tumor tissue is a very complex network that includes tumor cells, stromal cells, extracellular matrix, infiltrated immune cells, signaling molecules, and vascular components. The interplay between all these parts dictates tumor immunogenicity – the ability of tumor cells to induce the immune response of the host. Moreover, external factors, such as toxic substances or viruses, which infect tumor cells and are considered a part of the tumorigenic process, influence tumor cell behavior. Environmental influence can also disturb the tumor transcriptome and consequently cause aberrant human leukocyte antigen (HLA) expression that is a basis both for the activation of cytotoxic immune mechanisms and the antigen-presenting capability. Those impacts are important not only for tumor surveillance by the immune cells but also as key components that enable efficient immunotherapy protocols.
The goal of the Research Topic is to gather existing knowledge and propose future direction of research that involves mechanisms that control tumor immunogenicity. Through the understanding of tumor cells’ ability to interact with immune cells and the recognition of environmental influence on this communication, it is possible to predict tumor behavior and design specific approaches that can target certain aspects of the immunogenicity process in order to disable tumor growth and spreading.
Environmental influence on tumor immunogenicity is a general topic that includes, but is not limited to:
• molecular basis of tumor immunogenicity
• viral impact on the immune system and tumor development
• immunogenetic tools in cancer research
• environmental influence on HLA expression in tumors
• novel approaches to antitumor immunotherapies
• precision medicine based on immunosurveillance control
This topic welcomes full-length original articles and reviews covering all aspects of interplay between tumor environment and tumor immunogenicity. Papers should describe original research in vitro, original research on model organisms, or present clinical studies that are based on tumor immunogenicity recognition.
Keywords:
Tumor Immunogenicity; Environmental Influence; HLA Expression; Immunotherapy; Protocols Cytotoxic; Immune Mechanisms
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Tumor tissue is a very complex network that includes tumor cells, stromal cells, extracellular matrix, infiltrated immune cells, signaling molecules, and vascular components. The interplay between all these parts dictates tumor immunogenicity – the ability of tumor cells to induce the immune response of the host. Moreover, external factors, such as toxic substances or viruses, which infect tumor cells and are considered a part of the tumorigenic process, influence tumor cell behavior. Environmental influence can also disturb the tumor transcriptome and consequently cause aberrant human leukocyte antigen (HLA) expression that is a basis both for the activation of cytotoxic immune mechanisms and the antigen-presenting capability. Those impacts are important not only for tumor surveillance by the immune cells but also as key components that enable efficient immunotherapy protocols.
The goal of the Research Topic is to gather existing knowledge and propose future direction of research that involves mechanisms that control tumor immunogenicity. Through the understanding of tumor cells’ ability to interact with immune cells and the recognition of environmental influence on this communication, it is possible to predict tumor behavior and design specific approaches that can target certain aspects of the immunogenicity process in order to disable tumor growth and spreading.
Environmental influence on tumor immunogenicity is a general topic that includes, but is not limited to:
• molecular basis of tumor immunogenicity
• viral impact on the immune system and tumor development
• immunogenetic tools in cancer research
• environmental influence on HLA expression in tumors
• novel approaches to antitumor immunotherapies
• precision medicine based on immunosurveillance control
This topic welcomes full-length original articles and reviews covering all aspects of interplay between tumor environment and tumor immunogenicity. Papers should describe original research in vitro, original research on model organisms, or present clinical studies that are based on tumor immunogenicity recognition.
Keywords:
Tumor Immunogenicity; Environmental Influence; HLA Expression; Immunotherapy; Protocols Cytotoxic; Immune Mechanisms
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.