Development of mRNA Vaccines for Prevention and Therapy of Infectious and Oncological Diseases

  • 1,048

    Total Views and Downloads

About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 31 May 2025

  2. This Research Topic is still accepting articles.

Background

The rapid advancements in mRNA technology have opened new avenues for vaccine development, particularly in the prevention and treatment of infectious and oncological diseases. Lipid nanoparticles (LNP) have been used to facilitate the success of mRNA vaccines, providing a stable and efficient means of delivering mRNA into host cells. The nanoparticles protect the fragile mRNA from degradation and facilitate its uptake by cells, ensuring the effective production of the target antigen. This affects the design, optimization, and functionalization of LNPs, shedding light on their role in enhancing the efficacy and stability of mRNA vaccines. Beyond lipid nanoparticles, this issue will also explore other nanotechnology-enabled systems that hold promise for mRNA delivery. These include polymeric nanoparticles, lipid-polymer hybrid nanoparticles, and inorganic nanoparticles, each offering unique advantages and challenges. By examining these alternative delivery systems, we aim to provide a comprehensive overview of the nanotechnology landscape in mRNA vaccine development. mRNA vaccines have gained significant attention due to their success in the COVID-19 pandemic, demonstrating their ability to be rapidly developed and deployed. Unlike traditional vaccines, mRNA vaccines do not require the pathogen itself but use a synthetic mRNA sequence that encodes the antigen. This approach reduces the risk of infection and allows for quicker modifications to address emerging variants. Moreover, mRNA vaccines can be designed to express tumor-specific antigens, making them a promising tool for cancer immunotherapy. While the benefits of nanotechnology in mRNA vaccines are clear, it is equally important to address the safety and potential nanotoxicology concerns associated with these nanoscale delivery systems. This Research Topic will integrate discussions on the biocompatibility, biodistribution, and potential toxicity of lipid nanoparticles and other nanocarriers. Understanding the interactions between the nanoparticles and biological systems is crucial for ensuring the safety and efficacy of mRNA vaccines. Through a series of in-depth reviews and original research articles, this Research Topic will provide a platform for the latest advancements and insights in the field of nanotechnology for mRNA vaccines. We invite contributions that explore novel nanocarriers, address safety concerns, and propose innovative solutions to the challenges faced in this dynamic and impactful area of research. We expect that this Topic Collection will inspire further innovation and collaboration, ultimately advancing the field of mRNA vaccine technology and contributing to the global effort to combat infectious diseases.

This research topic aims to serve as a comprehensive resource for researchers, clinicians, and policymakers involved in the field of mRNA vaccines. By highlighting the latest advancements and addressing the challenges in mRNA vaccine development, we expect to accelerate the translation of this promising technology from the laboratory to the clinic, ultimately improving global health outcomes. Specific questions that need to be answered include the optimization of mRNA synthesis and stabilization, the development of efficient delivery systems, and the enhancement of immunogenicity and efficacy. Hypotheses to be tested may involve the comparative effectiveness of different nanocarriers and the safety profiles of these delivery systems.

To gather further insights into the development and application of mRNA vaccines, we welcome articles addressing, but not limited to, the following themes:
- Design and Optimization of mRNA Vaccines: Innovations in mRNA synthesis and stabilization.
- Delivery systems, such as lipid nanoparticles, for efficient mRNA delivery.
- Strategies to enhance the immunogenicity and efficacy of mRNA vaccines.
- Case studies and real-world data on the deployment of mRNA vaccines.
- Mechanisms of Action: Insights into the immune response elicited by mRNA vaccines.
- Mechanisms underlying the therapeutic effects of mRNA vaccines in oncology.
- Comparative studies with other vaccine platforms.
- Regulatory and Manufacturing Challenges.
- Scalable manufacturing processes and quality control measures.
- Addressing the cold chain requirements for mRNA vaccine distribution.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: mRNA vaccines; Infectious diseases; Cancer immunotherapy; Vaccine development; mRNA technology; Lipid nanoparticles; LPN; Immunogenicity

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Participating Journals

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Impact

  • 1,048Topic views
View impact