Innovative Tumor Therapies: Targeting Angiogenesis and Metabolism

Tumor therapy has evolved significantly over recent decades, yet tumors continue to develop resistance to conventional treatments. Two critical processes, angiogenesis and metabolic reprogramming, play pivotal roles in tumor growth and progression. Angiogenesis, forming new blood vessels, supplies essential nutrients and oxygen to tumors, enabling their expansion and metastasis. Concurrently, tumor cells undergo metabolic reprogramming to adapt to the tumor microenvironment and meet their heightened energy demands. Understanding the intricate relationship between these processes is crucial for developing innovative therapeutic strategies. Recent research has uncovered novel molecular pathways and regulatory mechanisms that link angiogenesis and metabolism, offering promising therapeutic targets. Despite advances in understanding these processes, their complexity presents significant hurdles in treatment development. By targeting both angiogenesis and metabolic pathways, we can potentially overcome resistance mechanisms and improve treatment efficacy. This Research Topic seeks to compile cutting-edge research and reviews that explore these connections, identify new therapeutic strategies, and evaluate their clinical potential. By highlighting these advances, we aim to foster collaboration and drive the development of more effective and personalized tumor treatments.

This research topic aims to address the challenge of effectively targeting tumor angiogenesis and metabolism in tumor therapy. The main objectives include exploring the molecular mechanisms linking these processes, identifying novel therapeutic targets, and evaluating the clinical potential of combined anti-angiogenic and metabolic therapies. By answering these questions, we hope to uncover new strategies that can overcome resistance mechanisms and improve treatment efficacy. This research will test hypotheses about the interplay between angiogenesis and metabolism and their role in tumor progression and resistance.

To gather further insights into the complex interplay between angiogenesis and metabolism in tumor therapy, we welcome articles addressing, but not limited to, the following themes:
- Molecular mechanisms linking angiogenesis and metabolism in tumors.
- Metabolic regulation of angiogenesis in the tumor microenvironment.
- Novel therapeutic targets and strategies that disrupt both angiogenesis and metabolic pathways.
- Preclinical and clinical studies evaluating combined anti-angiogenic and metabolic therapies.
- Biomarkers and imaging techniques for assessing angiogenesis and metabolic activity in tumors.
- The role of hypoxia in modulating angiogenesis and metabolism.
- Immune cell interactions with angiogenesis and metabolic processes in tumors.

Keywords: angiogenesis, cell metabolism, tumor therapy, endothelial cell, metabolic

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.