Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases

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Editorial

07 February 2020

Editorial: Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases

Elodie Ey

,

Thomas Bourgeron

,

Tobias M. Boeckers

,

Eunjoon Kim

and

Kihoon Han

3,574 views

11 citations

Editors

5

Institute for Basic Science (IBS)

Thomas Bourgeron

Institut Pasteur

Tobias Maria Boeckers

University of Ulm

College of Medicine, Korea University

Institut Pasteur

Impact

About

Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons.

In this Research Topic, we seek to establish a platform that promotes active and efficient publication of Shankopathy-related results and exchanges of opinions. We would like to solicit manuscripts on Shankopathies with focuses at various levels, including genes, proteins, cells, synapses, neural circuits, behaviors, and environments.

Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons.

In this Research Topic, we seek to establish a platform that promotes active and efficient publication of Shankopathy-related results and exchanges of opinions. We would like to solicit manuscripts on Shankopathies with focuses at various levels, including genes, proteins, cells, synapses, neural circuits, behaviors, and environments.

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Editors

Institute for Basic Science (IBS)

Thomas Bourgeron

Institut Pasteur

Tobias Maria Boeckers

University of Ulm

College of Medicine, Korea University

Institut Pasteur

Impact

140,802 Total views

109,206 Article views

27,326 Article downloads

4,270 Topic views

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Frontiers in Molecular Neuroscience

Molecular Neuroscience Archive, Brain Disease Mechanisms, Molecular Signalling and Pathways, Methods and Model Organisms, Neuroplasticity and Development

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Frontiers in Cellular Neuroscience

Cellular Neuroscience Archive, Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

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Frontiers in Systems Neuroscience

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Frontiers in Integrative Neuroscience

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Frontiers in Neural Circuits

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Frontiers in Synaptic Neuroscience

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