Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases

140.4K

views

95

authors

16

articles

Editorial

07 February 2020

Editorial: Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases

Elodie Ey

,

Thomas Bourgeron

,

Tobias M. Boeckers

,

Eunjoon Kim

and

Kihoon Han

3,574 views

11 citations

Editors

5

Institute for Basic Science (IBS)

Thomas Bourgeron

Institut Pasteur

Tobias Maria Boeckers

University of Ulm

College of Medicine, Korea University

Institut Pasteur

Impact

About

Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons.

In this Research Topic, we seek to establish a platform that promotes active and efficient publication of Shankopathy-related results and exchanges of opinions. We would like to solicit manuscripts on Shankopathies with focuses at various levels, including genes, proteins, cells, synapses, neural circuits, behaviors, and environments.

Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons.

In this Research Topic, we seek to establish a platform that promotes active and efficient publication of Shankopathy-related results and exchanges of opinions. We would like to solicit manuscripts on Shankopathies with focuses at various levels, including genes, proteins, cells, synapses, neural circuits, behaviors, and environments.

Download ebook

Share

Editors

Institute for Basic Science (IBS)

Thomas Bourgeron

Institut Pasteur

Tobias Maria Boeckers

University of Ulm

College of Medicine, Korea University

Institut Pasteur

Impact

140,356 Total views

108,887 Article views

27,204 Article downloads

4,265 Topic views

Published In

Journal Thumbnail

Frontiers in Molecular Neuroscience

Molecular Neuroscience Archive, Brain Disease Mechanisms, Molecular Signalling and Pathways, Methods and Model Organisms, Neuroplasticity and Development

Journal Thumbnail

Frontiers in Cellular Neuroscience

Cellular Neuroscience Archive, Non-Neuronal Cells, Cellular Neurophysiology, Cellular Neuropathology

Journal Thumbnail

Frontiers in Systems Neuroscience

Journal Thumbnail

Frontiers in Integrative Neuroscience

Journal Thumbnail

Frontiers in Neural Circuits

Journal Thumbnail

Frontiers in Synaptic Neuroscience

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic