About this Research Topic
Similarly to metazoans, yeast cells can exhibit several characteristics of apoptosis, including chromatin condensation, DNA breakage, flipping of phosphatidylserine to the outer membrane, production of reactive oxygen species, and cytochrome c release from the mitochondria. Yeast programmed cell death has been shown to occur in response to a variety of exogenous stimuli, such as oxidative stress, exposure to acetic acid and expression of mammalian pro-apoptotic proteins. This program is also inherent to the yeast life cycle, as aged mother cells and cells exposed to pheromone also display an apoptotic and necrotic phenotype. We are interested in manuscripts enhancing our understanding on PCD and its deregulation relevant in human pathologies and ageing. These include the identification of previously uncharacterized proteins involved in PCD and ageing, studies involving humanized yeasts, and yeast-based screens for drug discovery.
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