About this Research Topic
Plants and fungi used as medicines and their metabolites have a long history of treating and managing such diseases. It is reported that certain bioactive metabolites extracted from herbal medicines play a role in inhibiting osteoclast differentiation and promoting osteogenesis. Pharmacological strategies, therefore, focus on leveraging these properties to manage and treat osteolytic conditions effectively.
The research topic seeks contributions that discover effective herbal medicines, their metabolites, or chemically well-characterized extracts with the effect on the bone remodeling compartment. We welcome studies focused on the biological and molecular underpinnings of bone-vessel coupling and the role of herbal medicine in these contexts.
Studies should focus on the following subjects:
• Mechanisms underlying osteolytic diseases and related disorders.
• Innovative prevention and treatment strategies for osteolytic diseases.
• Molecular mechanisms of herbal medicine and their metabolites or chemically well-characterized extracts.
• Screening and evaluation of the active metabolites in herbal medicines.
• Studies on endothelial cells and endosseous vessels.
Please note:
1. Please self-assess your MS using the ConPhyMP tool (https://ga-online.org/best-practice/), and follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. All the manuscripts need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here). Importantly, please ascertain that the ethnopharmacological context is clearly described (pillar 3d) and that the material investigated is characterized in detail (pillars 2 a and b).
2. Clinical trial articles will be accepted for review only if they are randomized, double-blinded, and placebo-controlled. Statistical power analysis or a justification of the sample size is mandatory.
3. In silico studies like network analyses or docking studies are generally not accepted unless they are followed by an in vitro or in vivo analysis of the material under investigation.
Keywords: bone remodeling, Herbal medicine, osteolytic diseases, osteoclast differentiation, osteogenesis, bioactive metabolites, endosseous vessels, ethnopharmacology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.