About this Research Topic

Background

The study of natural herbal medicine and its mechanisms has a rich historical background, with bioactive compounds derived from nature or their modified analogues serving as invaluable resources for drug research. These bioactive molecules can regulate various cellular processes, such as the cell cycle, growth, mitosis, DNA replication and repair, transcriptional activities, translational functions, etc. Therefore, it is crucial to accurately analyze the intracellular action targets, regulatory pathways, and networks of these natural active molecules and their derivatives to uncover their molecular functional mechanisms and biosafety. In recent decades, omics technologies have effectively facilitated the systematic exploration of target screening, signal transduction, and regulatory networks in cells through high-throughput analysis of comprehensive molecular alterations induced by drug treatment. This significantly contributes to a comprehensive understanding of the precise mechanisms and toxic side effects of drugs, ultimately augmenting the efficacy and success rate of drug development. This greatly enhances our understanding of drug mechanisms and side effects, ultimately improving the effectiveness and success rate of drug development.

This research topic aims to comprehensively investigate the natural active molecular mechanisms using omics technology, encompassing the identification of targets for active compounds, assessment of off-target effects, exploration of regulatory signal networks, and other related aspects. The research will focus on elucidating the genetic, transcriptomic, proteomic, and metabolomic alterations in cells treated with natural bioactive molecules. Additionally, it will explore the molecular mechanisms underlying the regulation of disease occurrence and progression by these compounds. By employing single-cell omics analysis, the study will delve into the regulatory signal networks and mechanisms of bioactive natural compounds, ultimately contributing to the development of novel methodologies for studying these molecules.

To gather further insights in the mechanism study of natural bioactive molecules using omics technology, we welcome articles addressing, but not limited to, the following themes:
- The genetic, transcriptomic, proteomic, and metabolomic alterations in cellular under the treatment of natural bioactive molecules.
- The molecular mechanisms underlying the regulation of disease occurrence and progression by natural bioactive molecules.
- Single-cell omics analysis for investigating the regulatory signal networks and mechanisms of bioactive natural compounds.
- Development of a novel methodology for studying the natural bioactive molecules.

We welcome submissions of the following article types: Brief Research Report, Original Research, Data Report, Methods, Technology and Code.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Technology and Code

Keywords: Natural Bioactive Molecule, Genomics, Transcriptomics, Proteomics, Metabolomics, Post-Translational Modification, Multi-omics, Drug Target, Biomarker, Mechanism

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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