About this Research Topic
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe pulmonary conditions marked by inflammation, endothelial injury, and significant hypoxemia. Despite progress in supportive care, these conditions continue to exhibit high morbidity and mortality rates. The pulmonary endothelium is central to the pathogenesis of ALI/ARDS, mediating the complex interactions between inflammation, coagulation, and vascular permeability. Recent studies have highlighted the critical role of endothelial cells in these processes, yet the precise molecular mechanisms of endothelial dysfunction remain inadequately understood. Current research has begun to unravel these complexities, but significant gaps persist, particularly in identifying effective therapeutic targets. Addressing these gaps is crucial for developing interventions that can improve patient outcomes in ALI/ARDS.
This research topic aims to investigate the challenges and opportunities in targeting the pulmonary endothelium to mitigate ALI/ARDS. We intend to explore the intricacies of endothelial cell biology in the context of lung injury, focusing on pathophysiological processes that can be manipulated to restore pulmonary homeostasis. By examining recent advances, we seek to highlight the potential of endothelial cells in modulating inflammation, vascular tone, and fluid balance, thereby opening new therapeutic avenues. Our goal is to compile a comprehensive overview of current strategies, emerging therapies, and innovative research that are shaping the future of ALI/ARDS management.
To gather further insights into the complexities of pulmonary endothelium in ALI/ARDS, we welcome articles addressing, but not limited to, the following themes:
- The role of endothelial cells in the initiation and progression of ALI/ARDS.
- Molecular pathways contributing to endothelial barrier dysfunction.
- The interplay between the endothelium and immune cells in the alveolar space.
- Novel biomarkers for early detection and prognosis of endothelial damage.
- Therapeutic strategies targeting endothelial cell activation and repair.
- The impact of co-morbidities on endothelial function in the context of ALI/ARDS.
- Translational studies that bridge basic research with clinical applications.
We are particularly interested in manuscripts presenting innovative approaches to modulate endothelial function, including gene therapy, nanomedicine, and drug repurposing. Additionally, we encourage submissions utilizing cutting-edge technologies like organ-on-a-chip models, single-cell RNA sequencing, and bioinformatics to elucidate endothelial cell behavior in ALI/ARDS.
This research topic aims to investigate the challenges and opportunities in targeting the pulmonary endothelium to mitigate ALI/ARDS. We intend to explore the intricacies of endothelial cell biology in the context of lung injury, focusing on pathophysiological processes that can be manipulated to restore pulmonary homeostasis. By examining recent advances, we seek to highlight the potential of endothelial cells in modulating inflammation, vascular tone, and fluid balance, thereby opening new therapeutic avenues. Our goal is to compile a comprehensive overview of current strategies, emerging therapies, and innovative research that are shaping the future of ALI/ARDS management.
To gather further insights into the complexities of pulmonary endothelium in ALI/ARDS, we welcome articles addressing, but not limited to, the following themes:
- The role of endothelial cells in the initiation and progression of ALI/ARDS.
- Molecular pathways contributing to endothelial barrier dysfunction.
- The interplay between the endothelium and immune cells in the alveolar space.
- Novel biomarkers for early detection and prognosis of endothelial damage.
- Therapeutic strategies targeting endothelial cell activation and repair.
- The impact of co-morbidities on endothelial function in the context of ALI/ARDS.
- Translational studies that bridge basic research with clinical applications.
We are particularly interested in manuscripts presenting innovative approaches to modulate endothelial function, including gene therapy, nanomedicine, and drug repurposing. Additionally, we encourage submissions utilizing cutting-edge technologies like organ-on-a-chip models, single-cell RNA sequencing, and bioinformatics to elucidate endothelial cell behavior in ALI/ARDS.
Keywords: acute lung injury, ARDS, endothelium, therapeutic approaches, molecular mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
