About this Research Topic
Cancer immunotherapy has emerged as a promising approach for treating cancer by harnessing the body’s immune system to target and kill cancer cells. However, not all patients respond to current immunotherapies, highlighting the need for novel strategies. Recent research has identified alternative cell death pathways, such as necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and immunogenic cell death (ICD) as potential targets for cancer therapy. These forms of cell death play crucial roles in cancer cell elimination and the activation of immune responses. Understanding the specific involvement of these pathways in cancer immunotherapy could lead to the development of more effective and targeted treatments. Therefore, investigating the mechanisms and potential therapeutic implications of these cell death pathways in the context of cancer immunotherapy is a critical area of research. This research topic aims to explore and understand the role of these pathways in cancer treatment and their potential as targets for novel immunotherapeutic interventions.
The primary goal of this Research Topic is to address the specific involvement of necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD in cancer immunotherapy. While these cell death pathways have been recognized as important players in cancer progression, their potential as targets for immunotherapy remains a relatively unexplored area. By understanding the intricate mechanisms and crosstalk between these pathways and the immune system, this research aims to identify novel therapeutic targets to enhance the effectiveness of cancer immunotherapy.
Recent advances in cell death research have highlighted the distinct molecular pathways and signaling networks governing necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD. Moreover, emerging evidence suggests that these cell death mechanisms can modulate the tumor microenvironment and influence the anti-tumor immune response. By elucidating the precise roles of these pathways in shaping the immune landscape within the tumor, we can uncover new opportunities for targeted interventions that exploit the vulnerabilities of cancer cells while priming the immune system for a more potent anti-cancer response. This Research Topic seeks to consolidate the latest findings and perspectives in this rapidly evolving field, with the ultimate goal of driving the development of innovative cancer immunotherapies.
This Research Topic aims to explore the intricate interplay between the cell death pathways (necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD) and cancer immunotherapy. We encourage contributions in the form of original research articles, reviews, mini-reviews, and perspectives that provide insights into the role of cell death pathways in cancer immunotherapy and highlight opportunities for therapeutic intervention. We welcome submissions that advance our understanding of these complex interactions and contribute to the development of personalized and effective cancer treatments. Specific themes of interest include:
1. Molecular mechanisms underlying necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD in cancer immunotherapy.
2. Impact of these cell death pathways on tumor progression and immune evasion.
3. Characterizing functional compounds from natural products targeting these cell death pathways.
4. Annotating the pharmacological mechanisms of natural products on these pathways.
5. Crosstalk between these cell death pathways and the immune system.
6. Modulation of the tumor microenvironment by these cell death mechanisms.
7. Development of precision immunotherapies targeting these pathways.
The primary goal of this Research Topic is to address the specific involvement of necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD in cancer immunotherapy. While these cell death pathways have been recognized as important players in cancer progression, their potential as targets for immunotherapy remains a relatively unexplored area. By understanding the intricate mechanisms and crosstalk between these pathways and the immune system, this research aims to identify novel therapeutic targets to enhance the effectiveness of cancer immunotherapy.
Recent advances in cell death research have highlighted the distinct molecular pathways and signaling networks governing necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD. Moreover, emerging evidence suggests that these cell death mechanisms can modulate the tumor microenvironment and influence the anti-tumor immune response. By elucidating the precise roles of these pathways in shaping the immune landscape within the tumor, we can uncover new opportunities for targeted interventions that exploit the vulnerabilities of cancer cells while priming the immune system for a more potent anti-cancer response. This Research Topic seeks to consolidate the latest findings and perspectives in this rapidly evolving field, with the ultimate goal of driving the development of innovative cancer immunotherapies.
This Research Topic aims to explore the intricate interplay between the cell death pathways (necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD) and cancer immunotherapy. We encourage contributions in the form of original research articles, reviews, mini-reviews, and perspectives that provide insights into the role of cell death pathways in cancer immunotherapy and highlight opportunities for therapeutic intervention. We welcome submissions that advance our understanding of these complex interactions and contribute to the development of personalized and effective cancer treatments. Specific themes of interest include:
1. Molecular mechanisms underlying necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy, apoptosis, and ICD in cancer immunotherapy.
2. Impact of these cell death pathways on tumor progression and immune evasion.
3. Characterizing functional compounds from natural products targeting these cell death pathways.
4. Annotating the pharmacological mechanisms of natural products on these pathways.
5. Crosstalk between these cell death pathways and the immune system.
6. Modulation of the tumor microenvironment by these cell death mechanisms.
7. Development of precision immunotherapies targeting these pathways.
Keywords: Cancer immunotherapy, Necroptosis, Pyroptosis, Ferroptosis, Cuproptosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
