This Research Topic is the second volume of the “Development and standardization of assays to assess immunogenicity and correlates of protection of vaccines against respiratory viral infections’’ Community Series. Please see Volume 1
hereVaccination is a cornerstone in the control and prevention of infectious diseases, with its efficacy demonstrated in the eradication or reduction of diseases like smallpox, polio, and measles. As vaccinology progresses, the development and standardization of assays and models to evaluate vaccine immunogenicity and determine correlates of protection become crucial. This research into respiratory viral infections continues to unravel the complexities of vaccine responses, highlighting the need for standardized methodologies to ensure consistent and reliable data, which is vital for advancing vaccine research and public health initiatives.
This Research Topic aims to build upon the foundations set by the initial volume of this series, focusing on the compilation of recent research that addresses the ongoing challenges in the field of respiratory viral infections. It seeks to foster the development and standardization of immunogenicity assays and models that can accurately measure and predict vaccine efficacy. By enhancing assay reproducibility and establishing clear correlates of protection, this series aspires to streamline vaccine development processes and accelerate regulatory approvals, particularly in urgent public health scenarios.
To effectively cover the complexities of this field, this Research Topic encompasses a broad range of focal areas. We invite contributions that push the boundaries of current knowledge and technology. Submissions can include, but are not limited to, the following themes:
- Development and standardization of in vitro assays to assess humoral, cellular, or innate immune responses to respiratory pathogens.
- Advancements in in vitro or in vivo models to establish vaccine safety and correlates of protection against respiratory infections.
- Studies identifying immune response markers—innate, humoral, or cellular—that correlate with protection from infection or severe disease.
- Investigations into factors affecting the quality or magnitude of immune responses to respiratory pathogens.
- Reviews and perspectives on current challenges and future directions in vaccine immunogenicity and correlates of protection studies.
We welcome the submission of Original Research articles, Reviews, Mini-Reviews, Perspective articles, Opinion articles, and Commentaries to enhance understanding and continue the conversation in this vital area of public health and vaccine development.
We acknowledge the funding of the manuscripts published in this Research Topic by the Sclavo Vaccines Association. We hereby state publicly that Sclavo Vaccines Association has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, and unbiased by any specific policy or opinion of Sclavo Vaccines Association.