About this Research Topic
Ferroptosis is a type of regulated cell death that is dependent on iron and driven by excessive lipid peroxidation. Inflammation is a natural process that helps protect the body against various threats and maintain tissue balance. However, when inflammation becomes dysregulated, it can lead to immune system imbalances, cellular dysfunction, and ultimately cell death. Recent research has shown that activation of inflammation can also trigger ferroptosis. This process releases molecules associated with damage, which in turn stimulate the immune system and lead to further inflammation. Some anti-inflammatory drugs have been found to inhibit ferroptosis in certain cell models, while some ferroptosis inhibitors have shown anti-inflammatory effects in certain diseases. Immune cells, such as macrophages, T cells, and B cells, require iron for their functions, and iron is also important for various cellular processes, including Toll-like receptor 4 signaling and mitochondrial respiration.
This Research Topic will explore the relationship between ferroptosis and inflammation, and how understanding this relationship can lead to new treatment strategies for inflammatory diseases and cancer. The collection aims to explore the relationship between ferroptosis and different immune cells, as well as investigate the impact of ferroptosis on infection, inflammation, and malignancy. By understanding these connections, we hope to identify potential therapeutic targets and develop targeted drugs for these diseases.
We welcome submissions of Original Research, Methods, Brief Research Reports, and Review Articles that address a variety of sub-topics, with a focus on the following areas:
1. Ferroptosis and immune response (including ferroptosis-related inflammatory factors, DAMPs-induced cellular immune response)
2. Ferroptosis and inflammatory diseases
3. Ferroptosis and lipid metabolism
4. Targeted ferroptosis-related immunotherapy
5. Ferroptosis and organ damage
6. Ferroptosis and inflammation
7. Regulatory genes associated with ferroptosis and inflammation
8. Development and application of ferroptosis inhibitors and inducers
9. Ferroptosis and inflammatory signal transduction pathway
10. Ferroptosis and homeostasis of cellular oxidative stress
This Research Topic will explore the relationship between ferroptosis and inflammation, and how understanding this relationship can lead to new treatment strategies for inflammatory diseases and cancer. The collection aims to explore the relationship between ferroptosis and different immune cells, as well as investigate the impact of ferroptosis on infection, inflammation, and malignancy. By understanding these connections, we hope to identify potential therapeutic targets and develop targeted drugs for these diseases.
We welcome submissions of Original Research, Methods, Brief Research Reports, and Review Articles that address a variety of sub-topics, with a focus on the following areas:
1. Ferroptosis and immune response (including ferroptosis-related inflammatory factors, DAMPs-induced cellular immune response)
2. Ferroptosis and inflammatory diseases
3. Ferroptosis and lipid metabolism
4. Targeted ferroptosis-related immunotherapy
5. Ferroptosis and organ damage
6. Ferroptosis and inflammation
7. Regulatory genes associated with ferroptosis and inflammation
8. Development and application of ferroptosis inhibitors and inducers
9. Ferroptosis and inflammatory signal transduction pathway
10. Ferroptosis and homeostasis of cellular oxidative stress
Keywords: Ferroptosis, inflammation, immunity, lipid metabolism, inflammatory diseases, cancer, targeted drugs, targeted drugs tumor immunosuppressive niche, immunotherapy, chemotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
