About this Research Topic
Recent advances in omics technologies, encompassing genomics, transcriptomics, proteomics, and metabolomics, have revolutionized our ability to probe interactions at a molecular level. It allows researchers to analyze the entire complement of genes, proteins, or metabolites present in a biological sample, providing a comprehensive view of the molecular mechanisms underlying viral infections.
One key aspect of the viral-host nexus constitutes the host immune response toward viral infections. The immune system plays a critical role in recognizing and eliminating viral invaders, but viruses have evolved various strategies to evade or manipulate the host immune response. Understanding the viral infection pathway in our immune system is essential for developing new antiviral therapies and vaccines.
Overall, research on interactions at the viral-host nexus is a rapidly evolving field that holds great promise for advancing our understanding of viral infections and improving strategies for their prevention and treatment. By integrating omics insights with studies of immune modulation, researchers can gain a more comprehensive understanding of the molecular mechanisms underlying viral-host interactions.
The project will employ mass spectrometry-based omics analysis to identify potential protein interactions during viral infections. Additionally, it will investigate the host immune responses, focusing on the modulation of key signalling pathways such as NF-κB. The findings from this comprehensive study will contribute to a deeper understanding of viral pathogenesis, host responses, and potential cross-viral immune modulation strategies. This research project aims to explore the intricate interactions between diverse viruses, including Newcastle disease virus (NDV), Infectious Bursal Disease Virus (IBDV), Canine Parvovirus, Brucella, and other pathogens at the molecular and cellular levels.
1. mass spectrometry-based omics analysis to identify potential protein interactions during viral infections.
2. the host immune responses, focusing on the modulation of key signalling pathways such as NF-κB.
3. the understanding of viral pathogenesis, host responses, and potential cross-viral immune modulation strategies.
4. the interactions between diverse viruses, including Newcastle disease virus (NDV), Infectious Bursal Disease Virus (IBDV), Canine Parvovirus, Brucella, and other pathogens at the molecular and cellular levels.
One key aspect of the viral-host nexus constitutes the host immune response toward viral infections. The immune system plays a critical role in recognizing and eliminating viral invaders, but viruses have evolved various strategies to evade or manipulate the host immune response. Understanding the viral infection pathway in our immune system is essential for developing new antiviral therapies and vaccines.
Overall, research on interactions at the viral-host nexus is a rapidly evolving field that holds great promise for advancing our understanding of viral infections and improving strategies for their prevention and treatment. By integrating omics insights with studies of immune modulation, researchers can gain a more comprehensive understanding of the molecular mechanisms underlying viral-host interactions.
The project will employ mass spectrometry-based omics analysis to identify potential protein interactions during viral infections. Additionally, it will investigate the host immune responses, focusing on the modulation of key signalling pathways such as NF-κB. The findings from this comprehensive study will contribute to a deeper understanding of viral pathogenesis, host responses, and potential cross-viral immune modulation strategies. This research project aims to explore the intricate interactions between diverse viruses, including Newcastle disease virus (NDV), Infectious Bursal Disease Virus (IBDV), Canine Parvovirus, Brucella, and other pathogens at the molecular and cellular levels.
1. mass spectrometry-based omics analysis to identify potential protein interactions during viral infections.
2. the host immune responses, focusing on the modulation of key signalling pathways such as NF-κB.
3. the understanding of viral pathogenesis, host responses, and potential cross-viral immune modulation strategies.
4. the interactions between diverse viruses, including Newcastle disease virus (NDV), Infectious Bursal Disease Virus (IBDV), Canine Parvovirus, Brucella, and other pathogens at the molecular and cellular levels.
Keywords: Omic, Viral-Host interaction, Signalling Pathway, Immune Modulation, Antiviral Therapy, Vaccine
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