About this Research Topic
Preeclampsia is a pregnancy-related multisystem disorder that progresses over time and the main symptoms are proteinuria and/or hypertension along with severe end-organ failure. Preeclampsia affects 2.1–5.6% of pregnancies worldwide. Preeclampsia is the second most prevalent cause of maternal death worldwide and a major cause of morbidity in both mothers and fetuses. This condition is affected by various other diseases such as Diabetes, COVID-19, HIV, and other autoimmune diseases. This condition has many consequences, and every individual's tale is unique. Despite extensive research, the exact cause of preeclampsia remains elusive, and effective preventive and treatment strategies are lacking.
Currently, there are no biomarkers available for the diagnosis of preeclampsia, nor are there any medications specifically designed to treat the condition, and the molecular pathways involved remain elusive. While some studies suggest hormonal changes, such as β-hCG, may influence preeclampsia development, a deeper exploration is warranted. Addressing the multifaceted challenges posed by preeclampsia demands a comprehensive and interdisciplinary approach that integrates advancements in basic science, clinical research, and healthcare delivery. By leveraging recent discoveries and advancements, alongside a commitment to equitable access to care, collaborative efforts between researchers and healthcare providers can play a crucial role in reducing the global burden of preeclampsia and enhancing maternal and fetal health outcomes. Therefore, our primary goal is to explore recent advancements in understanding preeclampsia, with an emphasis on early detection and minimizing complications for both the mother and fetus. This encompasses elucidating the molecular mechanisms underlying the condition, identifying pertinent biomarkers, and discovering medications to effectively manage and prevent preeclampsia. By synthesizing current knowledge and proposing future directions, can contribute to advancing our understanding and management of preeclampsia.
In this Research Topic, we welcome primary data papers (full/short articles), perspectives, reviews, clinical trials, case reports, observational studies, and etiology of preeclampsia.
Articles may involve one or more of the following topics:
• Molecular mechanisms on preeclampsia development.
• Diagnosis and predictive methods for early detection of preeclampsia.
• Biomarkers for early detection of preeclampsia in pregnant women and women before pregnancy.
• Gene signature studies on the patient samples, metabolomics, proteomics, etc.
• Impact of various diseases including HIV, Diabetes, Cancer, and recent outbreaks like COVID-19 on preeclampsia patients.
• Research animal models, cell lines and methodologies to conduct research on preeclampsia condition.
• To identify gaps in current knowledge and propose avenues for future research and clinical practice.
Currently, there are no biomarkers available for the diagnosis of preeclampsia, nor are there any medications specifically designed to treat the condition, and the molecular pathways involved remain elusive. While some studies suggest hormonal changes, such as β-hCG, may influence preeclampsia development, a deeper exploration is warranted. Addressing the multifaceted challenges posed by preeclampsia demands a comprehensive and interdisciplinary approach that integrates advancements in basic science, clinical research, and healthcare delivery. By leveraging recent discoveries and advancements, alongside a commitment to equitable access to care, collaborative efforts between researchers and healthcare providers can play a crucial role in reducing the global burden of preeclampsia and enhancing maternal and fetal health outcomes. Therefore, our primary goal is to explore recent advancements in understanding preeclampsia, with an emphasis on early detection and minimizing complications for both the mother and fetus. This encompasses elucidating the molecular mechanisms underlying the condition, identifying pertinent biomarkers, and discovering medications to effectively manage and prevent preeclampsia. By synthesizing current knowledge and proposing future directions, can contribute to advancing our understanding and management of preeclampsia.
In this Research Topic, we welcome primary data papers (full/short articles), perspectives, reviews, clinical trials, case reports, observational studies, and etiology of preeclampsia.
Articles may involve one or more of the following topics:
• Molecular mechanisms on preeclampsia development.
• Diagnosis and predictive methods for early detection of preeclampsia.
• Biomarkers for early detection of preeclampsia in pregnant women and women before pregnancy.
• Gene signature studies on the patient samples, metabolomics, proteomics, etc.
• Impact of various diseases including HIV, Diabetes, Cancer, and recent outbreaks like COVID-19 on preeclampsia patients.
• Research animal models, cell lines and methodologies to conduct research on preeclampsia condition.
• To identify gaps in current knowledge and propose avenues for future research and clinical practice.
Keywords: Pre-eclampsia, syncytialization, trophoblast differentiation, human chorionic gonadotropin-β (β-hCG), Hypertension, Proteinuria, HELLP Syndrome, Eclampsia
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
