About this Research Topic
Transcription factors (TF) are proteins that bind to specific DNA sequences and regulate the transcription of target genes. They control various cellular processes, including cell proliferation, differentiation, and immune responses. In cancer, dysregulated TF activity can profoundly impact the tumor microenvironment, influencing immune cell recruitment, activation, and function. By modulating the expression of immune-related genes, TFs can either promote or suppress immune infiltration in the tumor, shaping the anti-tumor immune response. Cancer immune infiltration, the process by which immune cells infiltrate tumor tissues, is a critical aspect of the tumor microenvironment and plays a pivotal role in cancer progression and response to therapy. Understanding the regulatory role of TFs in cancer immune infiltration holds significant promise for the development of novel therapeutic strategies and biomarkers for cancer treatment.
The goal of this Research Topic is to decipher the intricate interplay between TFs and immune cells in the context of cancer immune infiltration. We are interested in studies exploring the function of TFs in cancer through multiple mechanisms, including direct transcriptional regulation of immune-related genes, crosstalk with signaling pathways involved in immune cell activation, and interacting with other cellular components of the tumor microenvironment. In summary, deciphering the regulatory role of transcription factors in cancer immune infiltration represents a crucial step towards unraveling the complexities of the tumor microenvironment and developing more effective immunotherapy strategies.
We welcome submissions of Original Research, Review/Mini-Review, and Perspective articles that include, but are not limited to, the following research areas:
1) Role of TFs in modulating the Tumor Immune Microenvironment in Different Cancer Types: Comparing and contrasting the transcriptional regulatory mechanisms underlying immune infiltration in various cancer types.
2) Single-cell Analysis of TF-mediated Immune Modulation: Utilizing single-cell RNA sequencing and spatial transcriptomics to dissect the heterogeneity of TF expression and activity in immune and stromal cells within the tumor microenvironment.
3) Epigenetic Regulation of TFs in Cancer Immune Response: Investigating how epigenetic modifications, such as DNA methylation and histone acetylation, regulate the expression and activity of transcription factors involved in cancer immune infiltration.
4) Biomarkers for Predicting Response to Immunotherapy: Identifying transcriptional signatures or regulatory networks associated with response or resistance to immune checkpoint blockade and other immunotherapies, and their clinical implications for patient stratification and treatment decisions.
5) Transcriptional Regulation of Immune Responses: Studies elucidating the role of transcription factors, non-coding RNAs, and epigenetic modifications in regulating immune cell function and tumor immune evasion.
6) Therapeutic Targeting of TFs in Cancer Immunotherapy: Evaluating the potential of targeting specific transcription factors or their downstream targets as novel immunotherapy strategies to enhance antitumor immune responses and overcome resistance mechanisms.
7) TF Networks in Tumor-associated Macrophages (TAMs): Characterizing transcription factor networks that govern the polarization and activity of TAMs, and their influence on tumor progression, metastasis, and therapeutic resistance.
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
The goal of this Research Topic is to decipher the intricate interplay between TFs and immune cells in the context of cancer immune infiltration. We are interested in studies exploring the function of TFs in cancer through multiple mechanisms, including direct transcriptional regulation of immune-related genes, crosstalk with signaling pathways involved in immune cell activation, and interacting with other cellular components of the tumor microenvironment. In summary, deciphering the regulatory role of transcription factors in cancer immune infiltration represents a crucial step towards unraveling the complexities of the tumor microenvironment and developing more effective immunotherapy strategies.
We welcome submissions of Original Research, Review/Mini-Review, and Perspective articles that include, but are not limited to, the following research areas:
1) Role of TFs in modulating the Tumor Immune Microenvironment in Different Cancer Types: Comparing and contrasting the transcriptional regulatory mechanisms underlying immune infiltration in various cancer types.
2) Single-cell Analysis of TF-mediated Immune Modulation: Utilizing single-cell RNA sequencing and spatial transcriptomics to dissect the heterogeneity of TF expression and activity in immune and stromal cells within the tumor microenvironment.
3) Epigenetic Regulation of TFs in Cancer Immune Response: Investigating how epigenetic modifications, such as DNA methylation and histone acetylation, regulate the expression and activity of transcription factors involved in cancer immune infiltration.
4) Biomarkers for Predicting Response to Immunotherapy: Identifying transcriptional signatures or regulatory networks associated with response or resistance to immune checkpoint blockade and other immunotherapies, and their clinical implications for patient stratification and treatment decisions.
5) Transcriptional Regulation of Immune Responses: Studies elucidating the role of transcription factors, non-coding RNAs, and epigenetic modifications in regulating immune cell function and tumor immune evasion.
6) Therapeutic Targeting of TFs in Cancer Immunotherapy: Evaluating the potential of targeting specific transcription factors or their downstream targets as novel immunotherapy strategies to enhance antitumor immune responses and overcome resistance mechanisms.
7) TF Networks in Tumor-associated Macrophages (TAMs): Characterizing transcription factor networks that govern the polarization and activity of TAMs, and their influence on tumor progression, metastasis, and therapeutic resistance.
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
Keywords: Transcription factors (TFs), Epigenetic regulator, Tumor microenvironment, Cancer Immunology, Immune infiltration, Tumor immune escape, Regulatory networks
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
