About this Research Topic
Lymphocytes, including T/B cells as well as innate lymphoid cells (ILCs), are at the forefront of the body's defense system playing a pivotal role in maintaining health and fighting off pathogens and cancer cells. Their function is tightly regulated by cell-cell interactions and by a plethora of soluble factors that trigger a complex network of signaling cascades, ultimately leading to the generation of an appropriate cell response and to the elimination of the pathogens or cancer cells.
Disruption of this delicate regulatory network can lead to a variety of diseases including autoimmunity, immunodeficiency, and cancer.
Therefore, understanding how signaling pathways are regulated is at the center of intense investigations since decades and the work of many brilliant researchers and scientists has been dedicated to unraveling the mysteries of these signaling networks. Despite important advances, significant molecular aspects of how lymphocyte function is regulated remain still obscure.
The aim of this field of research is to provide valuable insights that can contribute to the development of new treatments for human diseases.
In this new Research Topic, we encourage authors to contribute Original Research as well as Reviews, and Mini Reviews that delve into the mysteries of lymphocyte signaling from health to disease.
Topics include, but are not limited to the following:
1. Signaling pathways and transcription factors that drive lymphoid differentiation and functions and their deregulation in immunodeficiencies.
2. Analysis of immune regulatory networks underlying autoimmunity and hypersensitivity reactions and novel tools of therapeutic intervention.
3. Signals regulating the crosstalk between lymphoid cells and other immune and non-immune cells in the tumor microenvironment.
4. Key signaling molecules that can be targeted to improve immune responses to pathogens and cancer.
Disruption of this delicate regulatory network can lead to a variety of diseases including autoimmunity, immunodeficiency, and cancer.
Therefore, understanding how signaling pathways are regulated is at the center of intense investigations since decades and the work of many brilliant researchers and scientists has been dedicated to unraveling the mysteries of these signaling networks. Despite important advances, significant molecular aspects of how lymphocyte function is regulated remain still obscure.
The aim of this field of research is to provide valuable insights that can contribute to the development of new treatments for human diseases.
In this new Research Topic, we encourage authors to contribute Original Research as well as Reviews, and Mini Reviews that delve into the mysteries of lymphocyte signaling from health to disease.
Topics include, but are not limited to the following:
1. Signaling pathways and transcription factors that drive lymphoid differentiation and functions and their deregulation in immunodeficiencies.
2. Analysis of immune regulatory networks underlying autoimmunity and hypersensitivity reactions and novel tools of therapeutic intervention.
3. Signals regulating the crosstalk between lymphoid cells and other immune and non-immune cells in the tumor microenvironment.
4. Key signaling molecules that can be targeted to improve immune responses to pathogens and cancer.
Keywords: Lymphocyte Signaling, T/B cells, lymphoid cells, ILCs, lymphoid differentiation, autoimmunity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
