About this Research Topic
The adipose tissue is a complex organ with endocrine, metabolic, and immune regulatory roles. In cancer, adipocytes and lipid metabolism play crucial roles in tumor development, progression, and responsiveness to therapy. Specifically, adipocytes not only provide metabolic substrates for cancer cell proliferation but also produce signaling molecules capable of stimulating cell adhesion, migration, invasion, angiogenesis, and inflammation. In turn, cancer cells can reprogram adipocytes towards a more inflammatory state. This co-evolving cross-talk creates a vicious cycle that propels tumor growth and evolution.
Furthermore, malignant cells undergo metabolic reprogramming to support tumor growth. These mechanisms may be heightened in obesity, which is associated with an increased risk of developing several types of tumors. Over the last few decades, the prevalence of obesity has surged worldwide. Consequently, there is a growing interest in exploring the cellular mechanisms and molecular determinants that drive the contribution of adipocytes and adipose tissue to tumor development and progression. Additionally, diet, as an exogenous source of lipids with pro- or anti-inflammatory functions, has also been linked to cancer risk.
This Research Topic is dedicated to the latest advances in the role of obesity and metabolism in endocrine-related cancers. We encourage submissions of Original Research, Brief Research Reports, Reviews, Mini-reviews, Methods, Perspectives, and Opinion articles. These submissions should focus on, but not be limited to, the following topics concerning endocrine-related tumors:
● Adipocytes and lipids involvement in tumor development and progression;
● Metabolic coupling between cancer and stromal cells in the tumor microenvironment;
● New insight into lipidomics and metabolomics;
● The impact of metabolism reprogramming on therapy responsiveness;
● Obesity association with the risk of developing endocrine-related tumors;
● The role of lipids in ferroptosis-mediated tumor suppression;
● Metabolism-targeted treatments and adipocytes-based therapies;
● The role of diets with different lipids intakes on the outcomes of patients affected by endocrine-related tumors.
Furthermore, malignant cells undergo metabolic reprogramming to support tumor growth. These mechanisms may be heightened in obesity, which is associated with an increased risk of developing several types of tumors. Over the last few decades, the prevalence of obesity has surged worldwide. Consequently, there is a growing interest in exploring the cellular mechanisms and molecular determinants that drive the contribution of adipocytes and adipose tissue to tumor development and progression. Additionally, diet, as an exogenous source of lipids with pro- or anti-inflammatory functions, has also been linked to cancer risk.
This Research Topic is dedicated to the latest advances in the role of obesity and metabolism in endocrine-related cancers. We encourage submissions of Original Research, Brief Research Reports, Reviews, Mini-reviews, Methods, Perspectives, and Opinion articles. These submissions should focus on, but not be limited to, the following topics concerning endocrine-related tumors:
● Adipocytes and lipids involvement in tumor development and progression;
● Metabolic coupling between cancer and stromal cells in the tumor microenvironment;
● New insight into lipidomics and metabolomics;
● The impact of metabolism reprogramming on therapy responsiveness;
● Obesity association with the risk of developing endocrine-related tumors;
● The role of lipids in ferroptosis-mediated tumor suppression;
● Metabolism-targeted treatments and adipocytes-based therapies;
● The role of diets with different lipids intakes on the outcomes of patients affected by endocrine-related tumors.
Keywords: Adipocytes, Metabolism, Cancer, Obesity, Tumor development
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
