Alterations in immunometabolic pathways represent one of the hallmarks of numerous diseases. With the emergence of single-cell multi-omics technologies and model organisms, the interplays between metabolism and immunity and their underlying molecular mechanisms have been better understood. Infections by pathogens and intratumoral or symbiotic microorganisms moderate the host’s immune response and metabolism, thus involving various biological processes and pathogenesis. Importantly, therapeutic targeting of metabolomic vulnerabilities or co-targeting immunometabolism has shown promising efficacy.
To deepen the understanding of the interactions between metabolism and immunity, the following aspects need to be addressed:
1. The conservativity and adaptability of the immune system and metabolism within the context of biological evolution. 2. Functional alterations in the metabolic profile and immune ecosystem during pathogenesis, including in a variety of conditions such as cancers and autoimmune diseases. 3. The molecular mechanisms underlying pathogen-attributed diseases and potential therapeutic targets. 4. The development of new methodologies and resources, including experimental approaches, bioinformatics, organoid or animal models, etc.
This Research Topic aims to compile original research, reviews, systematic reviews, mini-reviews, perspective pieces, case reports, abstracts, and data reports focused on the trend and recent advancements in the knowledge of the interplay between Metabolism and Immunity. Potential topics of interest include, but are not limited to:
• Evolutionary characteristics of immunity and metabolism.
• The pathological roles of immunity and metabolism and their molecular mechanisms.
• How pathogenic infections and microbiota influence the host’s immunity and metabolism.
• The therapeutic or prognostic significance of metabolic and immune markers.
• The application of new model organisms and bioinformatics methods in the study of immunity and metabolism.
Alterations in immunometabolic pathways represent one of the hallmarks of numerous diseases. With the emergence of single-cell multi-omics technologies and model organisms, the interplays between metabolism and immunity and their underlying molecular mechanisms have been better understood. Infections by pathogens and intratumoral or symbiotic microorganisms moderate the host’s immune response and metabolism, thus involving various biological processes and pathogenesis. Importantly, therapeutic targeting of metabolomic vulnerabilities or co-targeting immunometabolism has shown promising efficacy.
To deepen the understanding of the interactions between metabolism and immunity, the following aspects need to be addressed:
1. The conservativity and adaptability of the immune system and metabolism within the context of biological evolution. 2. Functional alterations in the metabolic profile and immune ecosystem during pathogenesis, including in a variety of conditions such as cancers and autoimmune diseases. 3. The molecular mechanisms underlying pathogen-attributed diseases and potential therapeutic targets. 4. The development of new methodologies and resources, including experimental approaches, bioinformatics, organoid or animal models, etc.
This Research Topic aims to compile original research, reviews, systematic reviews, mini-reviews, perspective pieces, case reports, abstracts, and data reports focused on the trend and recent advancements in the knowledge of the interplay between Metabolism and Immunity. Potential topics of interest include, but are not limited to:
• Evolutionary characteristics of immunity and metabolism.
• The pathological roles of immunity and metabolism and their molecular mechanisms.
• How pathogenic infections and microbiota influence the host’s immunity and metabolism.
• The therapeutic or prognostic significance of metabolic and immune markers.
• The application of new model organisms and bioinformatics methods in the study of immunity and metabolism.
