Genomic alterations influencing altered energy metabolism and drug resistance in cancer therapy

Cancer therapy is a rapidly evolving field, with drug resistance posing a significant challenge to effective treatment. Drug resistance, whether intrinsic or acquired, often leads to treatment failure, as cancer cells adapt to the selective pressures imposed by therapeutic agents. This adaptation frequently involves alterations in energy metabolism, a hallmark of cancer cells, which enables them to survive and proliferate in hostile environments. Recent studies have highlighted the potential of targeting energy metabolism as a promising strategy for cancer treatment. However, the development of anti-cancer drugs from this perspective remains limited, and the exploration of drug resistance through the lens of energy metabolism is still in its nascent stages. While some anti-cancer drugs and tumor suppressor pathways are known to modify energy metabolism, these interactions are often overlooked, underscoring the need for further investigation into this complex relationship.

This research topic aims to explore the intricate relationship between genomic alterations, energy metabolism, and drug resistance in cancer therapy. By delving into the mechanisms of deviant energy metabolism, the research seeks to uncover novel therapeutic targets and strategies that can overcome drug resistance. The objective is to address key questions such as how different types of energy metabolism contribute to drug resistance and what new roles classic anti-cancer drugs may play in this context. Additionally, the research will test hypotheses related to the development of new compounds targeting energy metabolism in cancer cells.

To gather further insights into the interplay between energy metabolism and drug resistance in cancer therapy, we welcome articles addressing, but not limited to, the following themes:
- Insightful reviews exploring the relationship between energy metabolism and drug resistance in cancer therapy.
- Investigations into various types of energy metabolism (e.g., glucose, lipid, amino acid metabolism) and their roles in drug resistance across different therapeutic modalities, including chemotherapy, targeted therapy, and immunotherapy.
- Papers unraveling newly discovered compounds connected to energy metabolism in cancer therapy.
- Studies revealing new roles of classic anti-cancer drugs in energy metabolism.

Keywords: Energy Metabolism; Glucose Starvation, Lipid Metabolism, Cancer Cell Death; Drug Resistance; Chemoresistance; Targeted Therapy; Immunotherapy;

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.