Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) has been a serious threat to human health. The immune system plays an important defensive role in fighting off the invasion of tuberculosis infection, however, Mtb can evade the immune system through a variety of mechanisms. An in-depth study of the mechanism of Mtb infection is conducive to providing new ideas and strategies for the research and development of new tuberculosis prevention and control methods. After Mtb invades the lungs, it is first engulfed by macrophages, and the morphology and function of macrophages are continuously transformed, at the same time, the immune response is triggered to recruit other immune cells to form a dynamic spatial barrier structure-granuloma. A healthy host immune system can confine Mtb to granuloma to prevent its spread, and when the host immune system is abnormal, the granuloma structure will facilitate the spread of Mtb and trigger immunopathological damage and drug tolerance. However, so far, the formation of pulmonary granulomas and their immune dynamic regulatory mechanisms under Mtb infection are far from clear.
This Research Topic focuses on the immunopathology process during Mycobacterium tuberculosis complex infection. It aims to identify the relevant components of Mtb that promote immune escape and further elucidation of the immune escape mechanism of Mtb. This includes the identification of immune escape-related components in innate immune macrophages and the analysis of their regulatory mechanisms. Additionally, this Research Topic involves screening the key components of Mtb and Bacillus Calmette-Guérin (BCG) that can effectively induce host protective immunity from the perspective of pathogenic bacteria, and it can facilitate the development of new tuberculosis vaccines. This entails a deeper exploration of the characteristics of immune cells and the regulatory network of cell-to-cell interactions within granuloma tissues, to identify new immune cell subsets and understand their functions.
We welcome authors to contribute with Original Research, Reviews, Mini-reviews as well as other article types accepted in the journal that include, but are not limited to the following sub-themes:
1. Identification of the factors associated with tuberculosis pathogenicity, and elucidate the immune escape mechanism of Mycobacterium tuberculosis complex
2. Identification of pathogen-related factors in innate immune macrophages and analysis of their regulatory mechanisms
3. Exploring the key components in Mtb and BCG that can effectively induce host protective immunity (such as training immunity)
4. Investigation on the formation of pulmonary granulomas and their immune dynamic regulatory mechanisms under Mtb infection
5. Elucidating the molecular mechanism of granuloma regulation of immunopathology during tuberculosis infection
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) has been a serious threat to human health. The immune system plays an important defensive role in fighting off the invasion of tuberculosis infection, however, Mtb can evade the immune system through a variety of mechanisms. An in-depth study of the mechanism of Mtb infection is conducive to providing new ideas and strategies for the research and development of new tuberculosis prevention and control methods. After Mtb invades the lungs, it is first engulfed by macrophages, and the morphology and function of macrophages are continuously transformed, at the same time, the immune response is triggered to recruit other immune cells to form a dynamic spatial barrier structure-granuloma. A healthy host immune system can confine Mtb to granuloma to prevent its spread, and when the host immune system is abnormal, the granuloma structure will facilitate the spread of Mtb and trigger immunopathological damage and drug tolerance. However, so far, the formation of pulmonary granulomas and their immune dynamic regulatory mechanisms under Mtb infection are far from clear.
This Research Topic focuses on the immunopathology process during Mycobacterium tuberculosis complex infection. It aims to identify the relevant components of Mtb that promote immune escape and further elucidation of the immune escape mechanism of Mtb. This includes the identification of immune escape-related components in innate immune macrophages and the analysis of their regulatory mechanisms. Additionally, this Research Topic involves screening the key components of Mtb and Bacillus Calmette-Guérin (BCG) that can effectively induce host protective immunity from the perspective of pathogenic bacteria, and it can facilitate the development of new tuberculosis vaccines. This entails a deeper exploration of the characteristics of immune cells and the regulatory network of cell-to-cell interactions within granuloma tissues, to identify new immune cell subsets and understand their functions.
We welcome authors to contribute with Original Research, Reviews, Mini-reviews as well as other article types accepted in the journal that include, but are not limited to the following sub-themes:
1. Identification of the factors associated with tuberculosis pathogenicity, and elucidate the immune escape mechanism of Mycobacterium tuberculosis complex
2. Identification of pathogen-related factors in innate immune macrophages and analysis of their regulatory mechanisms
3. Exploring the key components in Mtb and BCG that can effectively induce host protective immunity (such as training immunity)
4. Investigation on the formation of pulmonary granulomas and their immune dynamic regulatory mechanisms under Mtb infection
5. Elucidating the molecular mechanism of granuloma regulation of immunopathology during tuberculosis infection
