Autoantibodies

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Editorial

02 April 2019

Editorial: Autoantibodies

Rikard Holmdahl

,

Falk Nimmerjahn

and

Ralf J. Ludwig

7,496 views

4 citations

Editors

3

University of Lübeck

Rikard Holmdahl

Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet (KI)

Falk Nimmerjahn

University of Erlangen Nuremberg

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Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to the manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves’ disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effects.

To foster knowledge in autoantibody-induced pathology and to encourage the development of urgently needed novel therapeutic strategies, we hope to stimulate a vivid discussion and interest in autoantibody-mediated diseases.

This Research Topic will comprise of Review and Original Research articles considering all aspects of autoantibodies. This includes their generation, morphology (i.e. glycosylation status) in health and disease, as well as the diverse mechanisms by which they lead to the induction of clinically overt autoimmune disease.

Autoantibodies are frequently observed in healthy individuals. In a minority of these individuals, they lead to the manifestation of autoimmune diseases, such as rheumatoid arthritis or Graves’ disease. Overall, more than 2.5% of the population is affected by autoantibody-driven autoimmune disease. Pathways leading to autoantibody-induced pathology greatly differ among different diseases, and autoantibodies directed against the same antigen, depending on the targeted epitope, can have diverse effects.

To foster knowledge in autoantibody-induced pathology and to encourage the development of urgently needed novel therapeutic strategies, we hope to stimulate a vivid discussion and interest in autoantibody-mediated diseases.

This Research Topic will comprise of Review and Original Research articles considering all aspects of autoantibodies. This includes their generation, morphology (i.e. glycosylation status) in health and disease, as well as the diverse mechanisms by which they lead to the induction of clinically overt autoimmune disease.

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Editors

University of Lübeck

Rikard Holmdahl

Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet (KI)

Falk Nimmerjahn

University of Erlangen Nuremberg

Impact

696,642 Total views

520,140 Article views

166,967 Article downloads

9,535 Topic views

Published In

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Frontiers in Immunology

Multiple Sclerosis and Neuroimmunology, B Cell Biology, T Cell Biology, Immunological Tolerance and Regulation, Inflammation, Cytokines and Soluble Mediators in Immunity, Molecular Innate Immunity, Autoimmune and Autoinflammatory Disorders

Journal Thumbnail

Frontiers in Neurology

Multiple Sclerosis and Neuroimmunology

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Frontiers in Medicine

Dermatology, Rheumatology

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